九种人类胚胎干细胞系的LongSAGE分析
LongSAGE profiling of nine human embryonic stem cell lines.
作者信息
Hirst Martin, Delaney Allen, Rogers Sean A, Schnerch Angelique, Persaud Deryck R, O'Connor Michael D, Zeng Thomas, Moksa Michelle, Fichter Keith, Mah Diana, Go Anne, Morin Ryan D, Baross Agnes, Zhao Yongjun, Khattra Jaswinder, Prabhu Anna-Liisa, Pandoh Pawan, McDonald Helen, Asano Jennifer, Dhalla Noreen, Ma Kevin, Lee Stephanie, Ally Adrian, Chahal Neil, Menzies Stephanie, Siddiqui Asim, Holt Robert, Jones Steven, Gerhard Daniela S, Thomson James A, Eaves Connie J, Marra Marco A
机构信息
Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada, V5Z 1L3.
出版信息
Genome Biol. 2007;8(6):R113. doi: 10.1186/gb-2007-8-6-r113.
To facilitate discovery of novel human embryonic stem cell (ESC) transcripts, we generated 2.5 million LongSAGE tags from 9 human ESC lines. Analysis of this data revealed that ESCs express proportionately more RNA binding proteins compared with terminally differentiated cells, and identified novel ESC transcripts, at least one of which may represent a marker of the pluripotent state.
为促进新型人类胚胎干细胞（ESC）转录本的发现，我们从9个人类胚胎干细胞系中生成了250万个长链分析基因表达标签（LongSAGE标签）。对这些数据的分析表明，与终末分化细胞相比，胚胎干细胞表达的RNA结合蛋白比例更高，并鉴定出了新型胚胎干细胞转录本，其中至少有一种可能代表多能状态的标志物。
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