阿尔茨海默病中冷漠的结构关联
Structural correlates of apathy in Alzheimer's disease.
作者信息
Apostolova Liana G, Akopyan Gohar G, Partiali Negar, Steiner Calen A, Dutton Rebecca A, Hayashi Kiralee M, Dinov Ivo D, Toga Arthur W, Cummings Jeffrey L, Thompson Paul M
机构信息
Department of Neurology, Laboratory of Neuro Imaging, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA.
出版信息
Dement Geriatr Cogn Disord. 2007;24(2):91-7. doi: 10.1159/000103914. Epub 2007 Jun 14.
BACKGROUND
Apathy is the most common noncognitive symptom in Alzheimer's disease (AD). The structural correlates of apathy in AD have not yet been described.
METHODS
We analyzed magnetic resonance imaging data of 35 AD patients with and without apathy.
RESULTS
There was a significant linear association between apathy severity and cortical gray matter atrophy in the bilateral anterior cingulate [Brodmann area (BA) 24; r = 0.39-0.42, p = 0.01] and left medial frontal cortex (BA 8 and 9; r = 0.4, p < 0.02). Left mean cingulate cortical thinning predicted the presence/absence of apathy at the trend level of significance.
CONCLUSION
Our study demonstrates a strong association between apathy and the integrity of medial frontal regions in AD.
背景
冷漠是阿尔茨海默病（AD）最常见的非认知症状。AD中冷漠的结构相关性尚未得到描述。
方法
我们分析了35例有或无冷漠症状的AD患者的磁共振成像数据。
结果
冷漠严重程度与双侧前扣带回[布罗德曼区（BA）24；r = 0.39 - 0.42，p = 0.01]和左侧内侧额叶皮质（BA 8和9；r = 0.4，p < 0.02）的皮质灰质萎缩之间存在显著的线性关联。左侧扣带回平均皮质变薄在趋势显著性水平上可预测冷漠的有无。
结论
我们的研究表明AD中冷漠与内侧额叶区域的完整性之间存在密切关联。
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