Lyoo In Kyoon, Sung Young Hoon, Dager Stephen R, Friedman Seth D, Lee Jun-Young, Kim Seog Ju, Kim Namkug, Dunner David L, Renshaw Perry F
McLean Hospital Brain Imaging Center, Harvarrd Medical School, Boston, MA, USA.
Bipolar Disord. 2006 Feb;8(1):65-74. doi: 10.1111/j.1399-5618.2006.00284.x.
This study was conducted to explore differences in cortical thickness between subjects with bipolar disorder and healthy comparison subjects using cortical surface-based analysis.
Brain magnetic resonance images were acquired from 25 subjects with bipolar disorder and 21 healthy comparison subjects. Cortical surface-based analysis was conducted using the Freesurfer application. Group differences in cortical thickness, defined by the distance from gray/white boundary to the pial surface, were assessed using statistical difference maps.
Subjects with bipolar disorder exhibited significantly decreased cortical thickness in left cingulate cortex, left middle frontal cortex, left middle occipital cortex, right medial frontal cortex, right angular cortex, right fusiform cortex and bilateral postcentral cortices, relative to healthy comparison subjects (all p < 0.001). Duration of illness in bipolar subjects was inversely correlated with the cortical thickness of the left middle frontal cortex.
Cortical thinning was present in multiple prefrontal cortices in bipolar disorder. There was also cortical thinning in sensory and sensory association cortices, which has not been reported in previous studies using region-of-interest or voxel-based morphometry methods. Cortical thinning observed in the current study may be related to impairment of emotional, cognitive, and sensory processing in bipolar disorder but longitudinal studies will be necessary to test this hypothesis.
本研究旨在通过基于皮质表面的分析，探讨双相情感障碍患者与健康对照者之间皮质厚度的差异。
对25名双相情感障碍患者和21名健康对照者进行脑磁共振成像扫描。使用Freesurfer软件进行基于皮质表面的分析。通过统计差异图评估皮质厚度的组间差异，皮质厚度由灰质/白质边界到软脑膜表面的距离定义。
与健康对照者相比，双相情感障碍患者在左侧扣带回皮质、左侧额中回皮质、左侧枕中回皮质、右侧额内侧皮质、右侧角回皮质、右侧梭状回皮质以及双侧中央后回皮质的皮质厚度显著降低（所有p<0.001）。双相情感障碍患者的病程与左侧额中回皮质的皮质厚度呈负相关。
双相情感障碍患者多个前额叶皮质存在皮质变薄。感觉及感觉联合皮质也存在皮质变薄，这在以往使用感兴趣区或基于体素的形态测量方法的研究中尚未见报道。本研究中观察到的皮质变薄可能与双相情感障碍患者的情绪、认知和感觉加工受损有关，但需要纵向研究来验证这一假设。
