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更新P300：P3a和P3b的整合理论。

Updating P300: an integrative theory of P3a and P3b.

作者信息

Polich John

机构信息

Cognitive Electrophysiology Laboratory, Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

出版信息

Clin Neurophysiol. 2007 Oct;118(10):2128-48. doi: 10.1016/j.clinph.2007.04.019. Epub 2007 Jun 18.

DOI:10.1016/j.clinph.2007.04.019
PMID:17573239
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2715154/
Abstract

The empirical and theoretical development of the P300 event-related brain potential (ERP) is reviewed by considering factors that contribute to its amplitude, latency, and general characteristics. The neuropsychological origins of the P3a and P3b subcomponents are detailed, and how target/standard discrimination difficulty modulates scalp topography is discussed. The neural loci of P3a and P3b generation are outlined, and a cognitive model is proffered: P3a originates from stimulus-driven frontal attention mechanisms during task processing, whereas P3b originates from temporal-parietal activity associated with attention and appears related to subsequent memory processing. Neurotransmitter actions associating P3a to frontal/dopaminergic and P3b to parietal/norepinephrine pathways are highlighted. Neuroinhibition is suggested as an overarching theoretical mechanism for P300, which is elicited when stimulus detection engages memory operations.

摘要

通过考虑影响P300事件相关脑电位（ERP）波幅、潜伏期及一般特征的因素，对其经验性和理论性发展进行了综述。详细阐述了P3a和P3b子成分的神经心理学起源，并讨论了目标/标准辨别难度如何调节头皮地形图。概述了P3a和P3b产生的神经位点，并提出了一种认知模型：P3a起源于任务处理过程中由刺激驱动的额叶注意机制，而P3b起源于与注意相关的颞顶叶活动，且似乎与随后的记忆处理有关。强调了将P3a与额叶/多巴胺能通路以及P3b与顶叶/去甲肾上腺素能通路相关联的神经递质作用。神经抑制被认为是P300的一种总体理论机制，当刺激检测涉及记忆操作时会引发P300。

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