更新P300：P3a和P3b的整合理论。
Updating P300: an integrative theory of P3a and P3b.
作者信息
Polich John
机构信息
Cognitive Electrophysiology Laboratory, Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
出版信息
Clin Neurophysiol. 2007 Oct;118(10):2128-48. doi: 10.1016/j.clinph.2007.04.019. Epub 2007 Jun 18.
Abstract
The empirical and theoretical development of the P300 event-related brain potential (ERP) is reviewed by considering factors that contribute to its amplitude, latency, and general characteristics. The neuropsychological origins of the P3a and P3b subcomponents are detailed, and how target/standard discrimination difficulty modulates scalp topography is discussed. The neural loci of P3a and P3b generation are outlined, and a cognitive model is proffered: P3a originates from stimulus-driven frontal attention mechanisms during task processing, whereas P3b originates from temporal-parietal activity associated with attention and appears related to subsequent memory processing. Neurotransmitter actions associating P3a to frontal/dopaminergic and P3b to parietal/norepinephrine pathways are highlighted. Neuroinhibition is suggested as an overarching theoretical mechanism for P300, which is elicited when stimulus detection engages memory operations.
摘要
通过考虑影响P300事件相关脑电位（ERP）波幅、潜伏期及一般特征的因素，对其经验性和理论性发展进行了综述。详细阐述了P3a和P3b子成分的神经心理学起源，并讨论了目标/标准辨别难度如何调节头皮地形图。概述了P3a和P3b产生的神经位点，并提出了一种认知模型：P3a起源于任务处理过程中由刺激驱动的额叶注意机制，而P3b起源于与注意相关的颞顶叶活动，且似乎与随后的记忆处理有关。强调了将P3a与额叶/多巴胺能通路以及P3b与顶叶/去甲肾上腺素能通路相关联的神经递质作用。神经抑制被认为是P300的一种总体理论机制，当刺激检测涉及记忆操作时会引发P300。
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本文引用的文献
1
Distributed cortical network for visual attention.视觉注意的分布式皮质网络。
J Cogn Neurosci. 1997 Jan;9(1):75-91. doi: 10.1162/jocn.1997.9.1.75.
2
Event-related potentials and recognition memory for low- and high-frequency words.事件相关电位与低频及高频词的再认记忆。
J Cogn Neurosci. 1992 Winter;4(1):69-79. doi: 10.1162/jocn.1992.4.1.69.
3
P300 as a measure of cognitive dysfunction from occupational and environmental insults.P300 作为职业和环境损伤所致认知功能障碍的测量指标。
Environ Health Prev Med. 1999 Oct;4(3):103-10. doi: 10.1007/BF02932264.
4
Evidence for attentional gradient in the serial position memory curve from event-related potentials.来自事件相关电位的系列位置记忆曲线中注意梯度的证据。
J Cogn Neurosci. 2007 Dec;19(12):2071-81. doi: 10.1162/jocn.2007.19.12.2071.
5
Target-to-target interval, intensity, and P300 from an auditory single-stimulus task.听觉单刺激任务中的靶间间隔、强度和P300。
Psychophysiology. 2007 Mar;44(2):245-50. doi: 10.1111/j.1469-8986.2007.00495.x.
6
Genes mediate the association between P3 amplitude and externalizing disorders.基因介导了P3波幅与外化性障碍之间的关联。
Psychophysiology. 2007 Jan;44(1):98-105. doi: 10.1111/j.1469-8986.2006.00471.x.
7
Distinguishing source memory and item memory: brain potentials at encoding and retrieval.区分源记忆和项目记忆：编码和检索时的脑电活动
Brain Res. 2006 Nov 6;1118(1):142-54. doi: 10.1016/j.brainres.2006.08.034. Epub 2006 Sep 14.
8
High gamma power is phase-locked to theta oscillations in human neocortex.高伽马功率与人类新皮层中的theta振荡锁相。
Science. 2006 Sep 15;313(5793):1626-8. doi: 10.1126/science.1128115.
9
P3a from auditory white noise stimuli.来自听觉白噪声刺激的P3a。
Clin Neurophysiol. 2006 May;117(5):1106-12. doi: 10.1016/j.clinph.2006.01.023. Epub 2006 Mar 27.
10
Meditation states and traits: EEG, ERP, and neuroimaging studies.冥想状态与特质：脑电图、事件相关电位及神经影像学研究
Psychol Bull. 2006 Mar;132(2):180-211. doi: 10.1037/0033-2909.132.2.180.
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