伴有单克隆免疫球蛋白M λ淋巴细胞凝集素的慢性淋巴细胞白血病
Chronic lymphocytic leukemia with a monoclonal immunoglobulin M lambda lymphocyte agglutinin.
作者信息
Orero M, Collado R, Pérez P L, Pacios A, Iglesias R, Martínez A, Miguel-Sosa A, Carbonell F
机构信息
Department of Hematology, Consorcio Hospital General, Valencia, Spain.
出版信息
Lab Hematol. 2007;13(2):56-8. doi: 10.1532/LH96.06043.
A case of chronic lymphocytic leukemia is described in which peripheral blood films showed lymphocyte agglutination. A serum factor responsible for the agglutination was demonstrated. The factor was dependent upon the presence of anticoagulant solutions and was more active at room temperature than at 37 degrees C. It could be identified as a monoclonal immunoglobulin M. This mechanism has not been previously described in lymphocyte agglutination.
本文描述了一例慢性淋巴细胞白血病患者，其外周血涂片显示淋巴细胞凝集。证实了一种导致凝集的血清因子。该因子依赖于抗凝剂溶液的存在，在室温下比在37℃时更具活性。它可被鉴定为单克隆免疫球蛋白M。这种机制此前在淋巴细胞凝集方面尚未有过描述。
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