Daristotle L, Engwall M J, Niu W Z, Bisgard G E
Department of Comparative Biosciences, University of Wisconsin, Madison 53706.
J Appl Physiol (1985). 1991 Oct;71(4):1254-60. doi: 10.1152/jappl.1991.71.4.1254.
We utilized selective carotid body (CB) perfusion while changing inspired O2 fraction in arterial isocapnia to characterize the non-CB chemoreceptor ventilatory response to changes in arterial PO2 (PaO2) in awake goats and to define the effect of varying levels of CB PO2 on this response. Systemic hyperoxia (PaO2 greater than 400 Torr) significantly increased inspired ventilation (VI) and tidal volume (VT) in goats during CB normoxia, and systemic hypoxia (PaO2 = 29 Torr) significantly increased VI and respiratory frequency in these goats. CB hypoxia (CB PO2 = 34 Torr) in systemic normoxia significantly increased VI, VT, and VT/TI; the ventilatory effects of CB hypoxia were not significantly altered by varying systemic PaO2. We conclude that ventilation is stimulated by systemic hypoxia and hyperoxia in CB normoxia and that this ventilatory response to changes in systemic O2 affects the CB O2 response in an additive manner.
我们在动脉等碳酸血症中改变吸入氧分数的同时，利用选择性颈动脉体（CB）灌注来表征清醒山羊对动脉血氧分压（PaO2）变化的非CB化学感受器通气反应，并确定不同水平的CB血氧分压对该反应的影响。在CB常氧期间，全身高氧（PaO2大于400 Torr）显著增加了山羊的吸入通气量（VI）和潮气量（VT），而全身低氧（PaO2 = 29 Torr）显著增加了这些山羊的VI和呼吸频率。全身常氧下的CB低氧（CB血氧分压 = 34 Torr）显著增加了VI、VT和VT/TI；不同的全身PaO2并未显著改变CB低氧的通气效应。我们得出结论，在CB常氧时，全身低氧和高氧会刺激通气，并且这种对全身氧变化的通气反应以累加方式影响CB氧反应。
