• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Reducible poly(2-dimethylaminoethyl methacrylate): synthesis, cytotoxicity, and gene delivery activity.可还原的聚（甲基丙烯酸 2-二甲氨基乙酯）：合成、细胞毒性及基因传递活性
J Control Release. 2007 Oct 8;122(3):217-225. doi: 10.1016/j.jconrel.2007.04.020. Epub 2007 May 10.
2
Reversibly shielded DNA polyplexes based on bioreducible PDMAEMA-SS-PEG-SS-PDMAEMA triblock copolymers mediate markedly enhanced nonviral gene transfection.基于生物可还原 PDMAEMA-SS-PEG-SS-PDMAEMA 三嵌段共聚物的可逆屏蔽 DNA 超分子复合物介导显著增强的非病毒基因转染。
Biomacromolecules. 2012 Mar 12;13(3):769-78. doi: 10.1021/bm201693j. Epub 2012 Feb 10.
3
PEGylated poly(2-(dimethylamino) ethyl methacrylate)/DNA polyplex micelles decorated with phage-displayed TGN peptide for brain-targeted gene delivery.聚乙二醇化聚（2-二甲氨基乙基甲基丙烯酸酯）/噬菌体展示靶向转甲状腺素蛋白囊泡肽修饰的 DNA 高分子复合胶束用于脑靶向基因递释。
Biomaterials. 2013 Mar;34(8):2117-29. doi: 10.1016/j.biomaterials.2012.11.050. Epub 2012 Dec 13.
4
Effects of the incorporation of a hydrophobic middle block into a PEG-polycation diblock copolymer on the physicochemical and cell interaction properties of the polymer-DNA complexes.将疏水性中间嵌段引入聚乙二醇-聚阳离子二嵌段共聚物对聚合物-脱氧核糖核酸复合物的物理化学性质和细胞相互作用特性的影响。
Biomacromolecules. 2008 Nov;9(11):3294-307. doi: 10.1021/bm800876v. Epub 2008 Oct 23.
5
Application of poly(2-(dimethylamino)ethyl methacrylate)-based polyplexes for gene transfer into human ovarian carcinoma cells.基于聚甲基丙烯酸2-(二甲氨基)乙酯的多聚体在基因转导入人卵巢癌细胞中的应用。
Int J Pharm. 2005 Nov 4;304(1-2):185-92. doi: 10.1016/j.ijpharm.2005.07.018. Epub 2005 Aug 29.
6
Functionalization of lignin through ATRP grafting of poly(2-dimethylaminoethyl methacrylate) for gene delivery.通过原子转移自由基聚合（ATRP）接枝聚（2-二甲氨基乙基甲基丙烯酸酯）对木质素进行功能化，用于基因传递。
Colloids Surf B Biointerfaces. 2015 Jan 1;125:230-7. doi: 10.1016/j.colsurfb.2014.11.018. Epub 2014 Nov 21.
7
The copolymer of Poly(2-dimethylaminoethyl methacrylate) and methacrylated chondroitin sulfate with low cytotoxicity for gene delivery.具有低细胞毒性的聚（2-二甲氨基乙基甲基丙烯酸酯）和甲基丙烯酰化硫酸软骨素共聚物用于基因传递。
Adv Healthc Mater. 2013 Nov;2(11):1458-68. doi: 10.1002/adhm.201200373. Epub 2013 Apr 25.
8
Design and biophysical characterization of bioresponsive degradable poly(dimethylaminoethyl methacrylate) based polymers for in vitro DNA transfection.用于体外 DNA 转染的生物响应性可降解聚（二甲基氨基乙基甲基丙烯酸酯）基聚合物的设计和生物物理特性研究。
Biomacromolecules. 2012 Feb 13;13(2):313-22. doi: 10.1021/bm2015174. Epub 2012 Jan 17.
9
Reduction biodegradable brushed PDMAEMA derivatives synthesized by atom transfer radical polymerization and click chemistry for gene delivery.通过原子转移自由基聚合和点击化学合成的可生物降解的刷状 PDMAEMA 衍生物用于基因传递。
Acta Biomater. 2013 Aug;9(8):7758-66. doi: 10.1016/j.actbio.2013.04.046. Epub 2013 May 7.
10
Assessment of cholesterol-derived ionic copolymers as potential vectors for gene delivery.评估胆固醇衍生的离子共聚物作为基因传递的潜在载体。
Biomacromolecules. 2013 Nov 11;14(11):4135-49. doi: 10.1021/bm4013088. Epub 2013 Oct 30.

引用本文的文献

1
Advances and prospects of RNA delivery nanoplatforms for cancer therapy.用于癌症治疗的RNA递送纳米平台的进展与展望
Acta Pharm Sin B. 2025 Jan;15(1):52-96. doi: 10.1016/j.apsb.2024.09.009. Epub 2024 Sep 14.
2
Thermal Solution Depolymerization of RAFT Telechelic Polymers.RAFT 遥爪聚合物的热解聚
ACS Macro Lett. 2024 Jul 16;13(7):806-811. doi: 10.1021/acsmacrolett.4c00286. Epub 2024 Jun 10.
3
Poly(N,N-dimethylaminoethyl methacrylate) as a bioactive polyelectrolyte-production and properties.聚（甲基丙烯酸N，N-二甲基氨基乙酯）作为一种生物活性聚电解质——制备与性能
R Soc Open Sci. 2023 Sep 20;10(9):230188. doi: 10.1098/rsos.230188. eCollection 2023 Sep.
4
Poly[2-(dimethylamino)ethyl methacrylate--ethylene dimethacrylate]nanogel by dispersion polymerization for inhibition of pathogenic bacteria.通过分散聚合法制备的聚[2-(二甲基氨基)乙基甲基丙烯酸酯-二甲基丙烯酸乙烯酯]纳米凝胶用于抑制病原菌
RSC Adv. 2021 Oct 13;11(53):33461-33470. doi: 10.1039/d1ra06231j. eCollection 2021 Oct 8.
5
Antibacterial properties of poly (,-dimethylaminoethyl methacrylate) obtained at different initiator concentrations in solution polymerization.溶液聚合中不同引发剂浓度下制备的聚（甲基丙烯酸 - 二甲氨基乙酯）的抗菌性能
R Soc Open Sci. 2022 Jan 12;9(1):211367. doi: 10.1098/rsos.211367. eCollection 2022 Jan.
6
Patchy Core/Shell, Magnetite/Silver Nanoparticles via Green and Facile Synthesis: Routes to Assure Biocompatibility.通过绿色简便合成法制备的片状核/壳结构磁铁矿/银纳米颗粒：确保生物相容性的途径
Nanomaterials (Basel). 2020 Sep 17;10(9):1857. doi: 10.3390/nano10091857.
7
PH-Responsive, Cell-Penetrating, Core/Shell Magnetite/Silver Nanoparticles for the Delivery of Plasmids: Preparation, Characterization, and Preliminary Evaluation.用于质粒递送的pH响应性、细胞穿透性核壳型磁铁矿/银纳米颗粒：制备、表征及初步评价
Pharmaceutics. 2020 Jun 17;12(6):561. doi: 10.3390/pharmaceutics12060561.
8
Charge-Shifting Polycations Based on ,-(dimethylamino)ethyl Acrylate for Improving Cytocompatibility During DNA Delivery.基于丙烯酸2-（二甲氨基）乙酯的电荷转移聚阳离子用于改善DNA递送过程中的细胞相容性
ACS Omega. 2020 Apr 16;5(16):9114-9122. doi: 10.1021/acsomega.9b03734. eCollection 2020 Apr 28.
9
Construction of Dimeric Drug-Loaded Polymeric Micelles with High Loading Efficiency for Cancer Therapy.构建具有高效载药能力的二聚体药物负载聚合物胶束用于癌症治疗。
Int J Mol Sci. 2019 Apr 22;20(8):1961. doi: 10.3390/ijms20081961.
10
Water-Dispersible Silica-Polyelectrolyte Nanocomposites Prepared via Acid-Triggered Polycondensation of Silicic Acid and Directed by Polycations.通过硅酸的酸引发缩聚反应并在聚阳离子的引导下制备的水分散性二氧化硅-聚电解质纳米复合材料。
Polymers (Basel). 2016 Mar 22;8(3):96. doi: 10.3390/polym8030096.

本文引用的文献

1
Novel bioreducible poly(amido amine)s for highly efficient gene delivery.用于高效基因递送的新型可生物还原聚（酰胺胺）
Bioconjug Chem. 2007 Jan-Feb;18(1):138-45. doi: 10.1021/bc060200l.
2
Visualization of the degradation of a disulfide polymer, linear poly(ethylenimine sulfide), for gene delivery.用于基因递送的二硫聚合物（线性聚（乙撑亚胺硫化物））降解的可视化。
Bioconjug Chem. 2007 Jan-Feb;18(1):13-8. doi: 10.1021/bc060113t.
3
Reducible poly(amido ethylenimine) directed to enhance RNA interference.用于增强RNA干扰的可还原聚（氨基乙撑亚胺）
Biomaterials. 2007 Apr;28(10):1912-7. doi: 10.1016/j.biomaterials.2006.12.019. Epub 2007 Jan 10.
4
Multiblock reducible copolypeptides containing histidine-rich and nuclear localization sequences for gene delivery.含有富含组氨酸和核定位序列的用于基因递送的多嵌段可还原共多肽。
Bioconjug Chem. 2006 Nov-Dec;17(6):1395-403. doi: 10.1021/bc060104k.
5
Polyplex gene delivery modulated by redox potential gradients.由氧化还原电位梯度调节的多聚体基因递送
J Drug Target. 2006 Sep;14(8):519-26. doi: 10.1080/10611860600834409.
6
Degradable gene carriers based on oligomerized polyamines.基于低聚多胺的可降解基因载体。
Eur J Pharm Sci. 2006 Dec;29(5):414-25. doi: 10.1016/j.ejps.2006.08.002. Epub 2006 Aug 12.
7
Reducible poly(amido ethylenimine)s designed for triggered intracellular gene delivery.用于触发细胞内基因递送的可还原聚（酰胺乙撑亚胺）
Bioconjug Chem. 2006 Sep-Oct;17(5):1233-40. doi: 10.1021/bc0602026.
8
The internalization route resulting in successful gene expression depends on both cell line and polyethylenimine polyplex type.导致成功基因表达的内化途径取决于细胞系和聚乙烯亚胺多聚体类型。
Mol Ther. 2006 Nov;14(5):745-53. doi: 10.1016/j.ymthe.2006.07.006. Epub 2006 Sep 15.
9
Disassembly of layer-by-layer films of plasmid DNA and reducible TAT polypeptide.质粒DNA与可还原TAT多肽的层层组装膜的拆解
Biomaterials. 2007 Jan;28(1):117-24. doi: 10.1016/j.biomaterials.2006.08.035. Epub 2006 Sep 8.
10
Gene transfer by means of lipo- and polyplexes: role of clathrin and caveolae-mediated endocytosis.通过脂质体和多聚体进行基因转移：网格蛋白和小窝介导的内吞作用的作用
J Liposome Res. 2006;16(3):237-47. doi: 10.1080/08982100600848819.

可还原的聚（甲基丙烯酸 2-二甲氨基乙酯）：合成、细胞毒性及基因传递活性

Reducible poly(2-dimethylaminoethyl methacrylate): synthesis, cytotoxicity, and gene delivery activity.

作者信息

You Ye-Zi, Manickam Devika Soundara, Zhou Qing-Hui, Oupický David

机构信息

Department of Pharmaceutical Sciences, Wayne State University, Detroit, MI 48202, USA.

出版信息

J Control Release. 2007 Oct 8;122(3):217-225. doi: 10.1016/j.jconrel.2007.04.020. Epub 2007 May 10.

DOI:10.1016/j.jconrel.2007.04.020
PMID:17574292
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2063492/
Abstract

Reducible polycations represent promising carriers of therapeutic nucleic acids. Oligomers of 2-dimethylaminoethyl methacrylate (DMAEMA) containing terminal thiol groups were synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization using difunctional chain transfer agent. Reducible poly(DMAEMA) (rPDMAEMA) was synthesized by oxidation of the terminal thiol groups, forming a polymer with disulfide bonds in the backbone. Physico-chemical properties of DNA polyplexes of rPDMAEMA were evaluated by dynamic and static light scattering methods, revealing lower structural density and DNA content than control PDMAEMA polyplexes. Cytotoxicity and transfection activity of rPDMAEMA-based DNA polyplexes were evaluated in vitro. In comparison with control PDMAEMA, only minimum toxic effects of rPDMAEMA were observed in a panel of cell lines. Transfection activity was tested in B16F10 mouse melanoma and six human pancreatic cancer cell lines. rPDMAEMA polyplexes showed a comparable or better activity than control PDMAEMA polyplexes.

摘要

可还原的聚阳离子是有前景的治疗性核酸载体。使用双官能链转移剂通过可逆加成-断裂链转移（RAFT）聚合反应合成了含有末端硫醇基的甲基丙烯酸2-二甲基氨基乙酯（DMAEMA）低聚物。通过末端硫醇基的氧化合成了可还原的聚（DMAEMA）（rPDMAEMA），形成了主链中带有二硫键的聚合物。通过动态和静态光散射方法评估了rPDMAEMA的DNA多聚体的物理化学性质，结果显示其结构密度和DNA含量低于对照PDMAEMA多聚体。在体外评估了基于rPDMAEMA的DNA多聚体的细胞毒性和转染活性。与对照PDMAEMA相比，在一组细胞系中仅观察到rPDMAEMA的最小毒性作用。在B16F10小鼠黑色素瘤细胞系和六种人胰腺癌细胞系中测试了转染活性。rPDMAEMA多聚体显示出与对照PDMAEMA多聚体相当或更好的活性。