Skibsted L, Sperling L, Hansen U, Hertz J
Department of Obstetrics and Gynaecology, Gentofte Hospital, Hellerup, Copenhagen, Denmark.
Hum Reprod. 1991 Jul;6(6):828-31. doi: 10.1093/oxfordjournals.humrep.a137436.
Salpingitis isthmica nodosa (SIN) is a condition of nodular thickening of the proximal Fallopian tube. The purpose of this study was to investigate the occurrence, distribution and frequency of SIN in Danish women salpingectomized because of tubal pregnancy or salpingitis and to correlate SIN with infertility, pregnancies, outcome of pregnancies, births, pelvic inflammatory disease and salpingitis. Sections from the isthmus were present in the specimens from 223 tubes from 193 patients and were analysed by the same pathologist. Originally, SIN was found in 12 patients but on re-examination, it was found in 24 patients. Ten women with SIN were bilaterally salpingectomized. Only one woman had SIN in both tubes. Women with SIN gave birth to as many children as women without SIN. After SIN had been diagnosed, no children were born, but this was not statistically different from the frequency of births in the non-SIN group after salpingectomy. Women with SIN had histological signs of salpingitis more often than women without SIN, but SIN complicated with salpingitis did not influence the number of children or tubal pregnancies. Women with SIN had a greater risk of two or more tubal pregnancies than women without SIN.
输卵管峡部结节性输卵管炎（SIN）是近端输卵管出现结节状增厚的一种病症。本研究的目的是调查因输卵管妊娠或输卵管炎而接受输卵管切除术的丹麦女性中SIN的发生率、分布情况及发生频率，并将SIN与不孕、妊娠、妊娠结局、分娩、盆腔炎和输卵管炎相关联。193例患者的223条输卵管标本中有峡部切片，由同一位病理学家进行分析。最初，12例患者被发现患有SIN，但重新检查后，发现24例患者患有SIN。10例患有SIN的女性接受了双侧输卵管切除术。只有1名女性双侧输卵管均患有SIN。患有SIN的女性生育的子女数量与未患SIN的女性相同。在诊断出SIN后，没有女性生育子女，但这与输卵管切除术后非SIN组的生育频率在统计学上并无差异。患有SIN的女性比未患SIN的女性更常出现输卵管炎的组织学迹象，但伴有输卵管炎的SIN并不影响子女数量或输卵管妊娠情况。患有SIN的女性发生两次或更多次输卵管妊娠的风险高于未患SIN的女性。
