在神经回路及其分子调控机制中寻找精神分裂症和双相情感障碍的独特内表型。
Searching for unique endophenotypes for schizophrenia and bipolar disorder within neural circuits and their molecular regulatory mechanisms.
作者信息
Benes Francine M
机构信息
Program in Structural and Molecular Neuroscience, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA.
出版信息
Schizophr Bull. 2007 Jul;33(4):932-6. doi: 10.1093/schbul/sbm064. Epub 2007 Jun 16.
Abstract
The endophenotype is a construct that has utility for the study of postmortem brains from patients with psychotic disorders. By identifying networks of genes that show changes in expression within specific neuronal populations implicated in the pathophysiology of schizophrenia and bipolar disorder, it may be possible to move toward understanding these disorders at the cellular and molecular levels. The ultimate goal is to characterize their respective underlying genotypes.
摘要
内表型是一种对研究患有精神障碍患者的死后大脑有用的概念。通过识别在与精神分裂症和双相情感障碍病理生理学相关的特定神经元群体中显示表达变化的基因网络，有可能在细胞和分子水平上朝着理解这些疾病迈进。最终目标是表征它们各自潜在的基因型。
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本文引用的文献
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