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本文引用的文献

1
DNA fragmentation is increased in non-GABAergic neurons in bipolar disorder but not in schizophrenia.双相情感障碍中非γ-氨基丁酸能神经元的DNA片段化增加，但精神分裂症中未出现这种情况。
Schizophr Res. 2007 Jul;93(1-3):33-41. doi: 10.1016/j.schres.2007.01.030. Epub 2007 Apr 17.
2
Genetic overlap between bipolar illness and event-related potentials.双相情感障碍与事件相关电位之间的遗传重叠。
Psychol Med. 2007 May;37(5):667-78. doi: 10.1017/S003329170600972X. Epub 2007 Jan 16.
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Familial resemblance for executive functions in families of schizophrenic and bipolar patients.精神分裂症和双相情感障碍患者家庭中执行功能的家族相似性。
Psychiatry Res. 2006 Nov 15;144(2-3):131-8. doi: 10.1016/j.psychres.2005.11.013. Epub 2006 Oct 2.
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Toward constructing an endophenotype strategy for bipolar disorders.迈向构建双相情感障碍的内表型策略。
Biol Psychiatry. 2006 Jul 15;60(2):93-105. doi: 10.1016/j.biopsych.2005.11.006. Epub 2006 Jan 9.
5
The expression of proapoptosis genes is increased in bipolar disorder, but not in schizophrenia.促凋亡基因的表达在双相情感障碍中增加，但在精神分裂症中未增加。
Mol Psychiatry. 2006 Mar;11(3):241-51. doi: 10.1038/sj.mp.4001758.
6
Embracing complexity, inching closer to reality.拥抱复杂性，逐步贴近现实。
Sci STKE. 2005 Aug 2;2005(295):pe40. doi: 10.1126/stke.2952005pe40.
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Temporal stability of saccadic task performance in schizophrenia and bipolar patients.精神分裂症和双相情感障碍患者扫视任务表现的时间稳定性。
Psychol Med. 2004 Jul;34(5):921-32. doi: 10.1017/s003329170300165x.
8
Density of glutamic acid decarboxylase 67 messenger RNA-containing neurons that express the N-methyl-D-aspartate receptor subunit NR2A in the anterior cingulate cortex in schizophrenia and bipolar disorder.精神分裂症和双相情感障碍患者前扣带回皮质中表达N-甲基-D-天冬氨酸受体亚基NR2A的含谷氨酸脱羧酶67信使核糖核酸神经元的密度
Arch Gen Psychiatry. 2004 Jul;61(7):649-57. doi: 10.1001/archpsyc.61.7.649.
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Molecular evidence for mitochondrial dysfunction in bipolar disorder.双相情感障碍中线粒体功能障碍的分子证据。
Arch Gen Psychiatry. 2004 Mar;61(3):300-8. doi: 10.1001/archpsyc.61.3.300.
10
In vivo evidence in the brain for lithium inhibition of glycogen synthase kinase-3.锂抑制糖原合酶激酶-3在大脑中的体内证据。
Neuropsychopharmacology. 2004 Jan;29(1):32-8. doi: 10.1038/sj.npp.1300283.

在神经回路及其分子调控机制中寻找精神分裂症和双相情感障碍的独特内表型。

Searching for unique endophenotypes for schizophrenia and bipolar disorder within neural circuits and their molecular regulatory mechanisms.

作者信息

Benes Francine M

机构信息

Program in Structural and Molecular Neuroscience, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA.

出版信息

Schizophr Bull. 2007 Jul;33(4):932-6. doi: 10.1093/schbul/sbm064. Epub 2007 Jun 16.

DOI:10.1093/schbul/sbm064
PMID:17575303
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2632324/
Abstract

The endophenotype is a construct that has utility for the study of postmortem brains from patients with psychotic disorders. By identifying networks of genes that show changes in expression within specific neuronal populations implicated in the pathophysiology of schizophrenia and bipolar disorder, it may be possible to move toward understanding these disorders at the cellular and molecular levels. The ultimate goal is to characterize their respective underlying genotypes.

摘要

内表型是一种对研究患有精神障碍患者的死后大脑有用的概念。通过识别在与精神分裂症和双相情感障碍病理生理学相关的特定神经元群体中显示表达变化的基因网络，有可能在细胞和分子水平上朝着理解这些疾病迈进。最终目标是表征它们各自潜在的基因型。