Yamashita Kazumi, Nabeshima Atsuko, Hara Yuichi, Okochi Jiro
Palliative Care Unit, Haradoi Hospital.
Nihon Ronen Igakkai Zasshi. 2007 May;44(3):345-50. doi: 10.3143/geriatrics.44.345.
The aim of this study was to evaluate the relationship between maximum opioid dose and body weight, age, and primary site in terminal cancer patients in a palliative care unit.
Medical records of 152 terminal cancer patients were reviewed retrospectively. Body weight, primary tumor site, age, and analgesic state were used as independent variables, and the maximum opioid dose was used as a dependent variable.
There was no correlation between body weight and maximum opioid requirement. Selected independent variables were age and location of the primary lesion in the lower gastrointestinal tract. Maximum opioid dose was negatively correlated with age (P < or =0.0001). Opioid needs of age <65 was 344.2 mg/day oral morphine equivalent, but age 65-74 was 168.5, and age > or =75 was 116.9 mg/day.
Elderly cancer patients required a lower amount of opioid analgesia than younger adults. The ratio for age <65, 65-74, and > or =75 was about 1:1/2:1/3.
本研究旨在评估姑息治疗病房中晚期癌症患者的最大阿片类药物剂量与体重、年龄及原发部位之间的关系。
回顾性分析152例晚期癌症患者的病历。将体重、原发肿瘤部位、年龄及镇痛状态作为自变量，最大阿片类药物剂量作为因变量。
体重与最大阿片类药物需求量之间无相关性。选定的自变量为年龄及下消化道原发病变部位。最大阿片类药物剂量与年龄呈负相关（P≤0.0001）。年龄<65岁患者的阿片类药物需求量为口服吗啡当量344.2毫克/天，而年龄65 - 74岁患者为168.5毫克/天，年龄≥75岁患者为116.9毫克/天。
老年癌症患者比年轻成年人需要的阿片类镇痛药物量更少。年龄<65岁、65 - 74岁及≥75岁患者的比例约为1:1/2:1/3。
