Giannopoulos George, Kavantzas Nikolaos, Parasi Aikaterini, Tiniakos Dina, Peros George, Tzanakis Nikolaos, Patsouris Efstratios, Pavlakis Kitty
Fourth Surgical Department, Attikon Hospital, University of Athens, Athens, Greece.
Pancreas. 2007 Jul;35(1):47-52. doi: 10.1097/mpa.0b013e31804bfbab.
To evaluate multiple morphometric microvascular characteristics in addition to microvascular density (MVD) in pancreatic ductal and ampullary adenocarcinomas and provide a better approach in examining the relationship among angiogenesis, several clinicopathologic parameters, and prognosis.
Histological sections from 32 pancreatic ductal and 17 ampullary adenocarcinomas, immunostained with CD34, were evaluated by image analysis for the quantification of MVD, total vascular area, and microvascular branching, as well as several morphometric parameters related to the vessel size and shape factor.
In pancreatic ductal carcinoma, higher levels of MVD, total vascular area, branching, and shape factor were related to N1 tumors. Moreover, MVD, shape factor, and minor axis length were identified as independent prognostic factors of survival. In the ampullary carcinoma group, higher shape factor values were observed in well-differentiated tumors.
In pancreatic ductal carcinoma patients, the assessment of MVD and several morphometric microvascular characteristics provides significant prognostic information. The biologic behavior of the ampullary carcinomas does not seem to be dependent on any of the above mentioned factors of angiogenesis.
除评估微血管密度（MVD）外，还评估胰腺导管腺癌和壶腹腺癌的多种形态计量微血管特征，并为研究血管生成、若干临床病理参数与预后之间的关系提供更好的方法。
对32例胰腺导管腺癌和17例壶腹腺癌的组织切片进行CD34免疫染色，通过图像分析评估MVD、总血管面积、微血管分支以及与血管大小和形状因子相关的若干形态计量参数。
在胰腺导管癌中，较高水平的MVD、总血管面积、分支和形状因子与N1期肿瘤相关。此外，MVD、形状因子和短轴长度被确定为生存的独立预后因素。在壶腹癌组中，高分化肿瘤的形状因子值较高。
对于胰腺导管癌患者，评估MVD和多种形态计量微血管特征可提供重要的预后信息。壶腹癌的生物学行为似乎不依赖于上述任何血管生成因素。
