Gu Xiao-Lan, Mao Jin-yuan, Shan Zhong-yan, Teng Xiao-chun, Teng Di, Guan Hai-xia, Li Yu-shu, Yu Xiao-hui, Fan Chen-ling, Chong Wei, Yang Fan, Dai Hong, Yu Yang, Li Jia, Chen Yan-yan, Zhao Dong, Yang Rong, Jiang Ya-qiu, Li Chen-yang, Teng Wei-ping
Department of Endocrinology, 1st Affiliated Hospital, China Medical University, Shenyang 110001, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2007 Jan;28(1):53-6.
To investigate the effect of cigarette smoking on thyroid gland volume, thyroid function and thyroid autoantibodies in the areas with different iodine intakes.
A cross-sectional epidemiological study in Panshan (mild iodine-deficient area), Zhangwu (more than adequate iodine intake area) and Huanghua (iodine-excessive area) was conducted in 3761 subjects in 1999.80.2 % of them were followed up in 2004. Questionnaires, thyroid function, thyroid autoantibodies, urinary iodine concentration,and thyroid B ultrasound were performed.
The prevalence of goiter was higher in smokers than in non-smokers (15.1% vs. 11.5%, P< 0.05). The average thyroid volume was higher in smokers with phenomenon more obvious in Panshan and Huanghua areas. Data from logistic analysis showed that smoking cigarette was an independent risk factor of goiter. There was no difference in serum TSH and Tg level between smokers and non-smokers. The positive rate of TPOAb (>100 IU/ml) was higher in smokers than in non-smokers(10.8% vs. 9.0 % , P <0.05) and was especially obvious in Huanghua area. Smoking was a independent risk factor of increasing positive rate of TPOAb. During the prospective observation,it was found that the incidence of positive TPOAb(>,100 IU/ml) was 7.4% in the subjects that were from non-smokers turning to smokers and 2.9% in those whose smoking behavior did not change. Logistic analysis indicated that the shifting from non-smoking to smoking was independent risk factor for the increase on high incidence of positive TPOAb.
Smoking cigarette was a independent risk factor of goiter. Smoking was also a risk factor of increasing TPOAb positive rate. Shifting from not smoking to smoking was an independent risk factor of increasing high incidence of positive TPOAb.
探讨吸烟对不同碘摄入地区甲状腺体积、甲状腺功能及甲状腺自身抗体的影响。
1999年对盘山（轻度碘缺乏地区）、彰武（碘摄入充足地区）和黄骅（碘过量地区）的3761名受试者进行了横断面流行病学研究。2004年对其中80.2%的受试者进行了随访。进行了问卷调查、甲状腺功能、甲状腺自身抗体、尿碘浓度及甲状腺B超检查。
吸烟者甲状腺肿患病率高于非吸烟者（15.1%对11.5%，P<0.05）。吸烟者的平均甲状腺体积更大，在盘山和黄骅地区这种现象更明显。逻辑分析数据显示，吸烟是甲状腺肿的独立危险因素。吸烟者与非吸烟者的血清促甲状腺激素（TSH）和甲状腺球蛋白（Tg）水平无差异。吸烟者甲状腺过氧化物酶抗体（TPOAb，>100 IU/ml）阳性率高于非吸烟者（10.8%对9.0%，P<0.05），在黄骅地区尤为明显。吸烟是TPOAb阳性率升高的独立危险因素。在前瞻性观察中发现，从不吸烟者转变为吸烟者的受试者中TPOAb（>100 IU/ml）阳性发生率为7.4%，吸烟行为未改变者为2.9%。逻辑分析表明，从不吸烟转变为吸烟是TPOAb高阳性发生率增加的独立危险因素。
吸烟是甲状腺肿的独立危险因素。吸烟也是TPOAb阳性率升高的危险因素。从不吸烟转变为吸烟是TPOAb高阳性发生率增加的独立危险因素。
