GRP78 启动子和 3'UTR 多态性与中国汉族人群慢性乙型肝炎病毒感染易感性无关。
Lack of association between the GRP78 polymorphisms in the promoter and 3' UTR and susceptibility to chronic HBV infection in a Chinese Han population.
机构信息
Institute of Oncology, Affiliated Tumor Hospital, Guangzhou Medical College, Guangzhou, PR China.
出版信息
BMC Med Genet. 2010 Jun 2;11:83. doi: 10.1186/1471-2350-11-83.
BACKGROUND
Hepatitis B virus (HBV) infection causes large amount of unfolding or false-folding protein accumulation in the endoplasmic reticulum (ER), which in turn induces the expression of glucose-regulated protein 78 (GRP78). The aim in the present study was to analyse the potential association between GRP78 single-nucleotide polymorphisms (SNPs) and the risk of HBV infection.
METHODS
The associations between seven common GRP78 polymorphisms in the promoter (rs391957, rs17840762, rs17840761, rs11355458) and in the 3' untranslated region (UTR) (rs16927997, rs1140763, rs12009) and possible risk of chronic HBV infection were assessed in a case-control study. 496 cases and 539 individually matched healthy controls were genotyped.
RESULTS
Overall, no associations were observed in genotypic analyses. In addition, haplotypes and diplotypes combining those SNPs in the promoter or in the 3' UTR in high linkage disequilibrium (LD) were also not associated with HBV risk.
CONCLUSION
These observations do not support a role for GRP78 polymorphisms in HBV infection in a predominantly Chinese Han population.
背景
乙型肝炎病毒（HBV）感染会导致内质网（ER）中大量未折叠或错误折叠的蛋白质积累，进而诱导葡萄糖调节蛋白 78（GRP78）的表达。本研究旨在分析 GRP78 单核苷酸多态性（SNPs）与 HBV 感染风险之间的潜在关联。
方法
在病例对照研究中，评估了启动子（rs391957、rs17840762、rs17840761、rs11355458）和 3'非翻译区（UTR）（rs16927997、rs1140763、rs12009）中七个常见 GRP78 多态性与慢性 HBV 感染的可能风险之间的关联。对 496 例病例和 539 例个体匹配的健康对照进行了基因分型。
结果
总体而言，在基因型分析中未观察到关联。此外，在高度连锁不平衡（LD）下组合启动子或 3'UTR 中这些 SNP 的单倍型和双等位基因也与 HBV 风险无关。
结论
这些观察结果不支持 GRP78 多态性在主要为汉族人群的 HBV 感染中的作用。
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