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1993年至2002年脊柱转移瘤手术后的全国住院患者并发症及预后情况。

National inpatient complications and outcomes after surgery for spinal metastasis from 1993-2002.

作者信息

Patil Chirag G, Lad Shivanand P, Santarelli Justin, Boakye Maxwell

机构信息

Department of Neurosurgery, Stanford University School of Medicine, Stanford, California, USA.

出版信息

Cancer. 2007 Aug 1;110(3):625-30. doi: 10.1002/cncr.22819.

Abstract

BACKGROUND

Information regarding patient outcomes, complications, and mortality after surgery for spinal metastasis has previously been derived from single-institution series. The aim of this study was to report inpatient mortality, complications, and outcomes on a national level.

METHODS

The National Inpatient Sample (NIS) was utilized to identify 26,233 admissions of surgically managed spinal metastasis in the U.S. from 1993 through 2002. Multivariate analysis was performed to analyze the effects of patient and hospital characteristics on outcomes such as mortality, complications, discharge disposition, and length of stay.

RESULTS

The in-hospital mortality rate was 5.6% and the complication rate was 21.9%. Pulmonary (6.7%) and postoperative hemorrhages or hematomas (5.9%) were the most common complications reported. A single postoperative complication increased the mean length of stay (LOS) by 7 days and the mortality rate by 11%. Multivariate analysis showed that complications were more likely in older patients and in patients with 2 or more comorbidities. With patients having no comorbidities as the reference group, 1 comorbidity increased the risk of in-hospital death by almost 4-fold. Mortality was significantly higher in men, in patients who had postoperative complications, and in patients who were operated in the earlier (1993-1997) year group.

CONCLUSIONS

A national perspective is provided on inpatient complications and outcomes after surgery for spinal metastasis in the U.S. The significant negative effect of postoperative complications on mortality and resource utilization is demonstrated. Furthermore, preoperative comorbidity is identified as an important risk factor and its impact is defined on patient outcomes.

摘要

背景

此前关于脊柱转移瘤手术后患者预后、并发症及死亡率的信息来源于单机构系列研究。本研究的目的是报告全国范围内的住院死亡率、并发症及预后情况。

方法

利用国家住院患者样本(NIS)识别1993年至2002年在美国接受手术治疗的26233例脊柱转移瘤患者。进行多变量分析以分析患者和医院特征对死亡率、并发症、出院处置及住院时间等预后指标的影响。

结果

住院死亡率为5.6%,并发症发生率为21.9%。报告的最常见并发症为肺部并发症(6.7%)及术后出血或血肿(5.9%)。单一术后并发症使平均住院时间延长7天,死亡率增加11%。多变量分析显示,老年患者及患有2种或更多合并症的患者更易发生并发症。以无合并症患者作为参照组,1种合并症使院内死亡风险增加近4倍。男性、有术后并发症的患者及在较早年份组(1993 - 1997年)接受手术的患者死亡率显著更高。

结论

提供了关于美国脊柱转移瘤手术后住院并发症及预后的全国性观点。证明了术后并发症对死亡率和资源利用有显著负面影响。此外,术前合并症被确定为重要危险因素,并明确了其对患者预后的影响。

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