Marrakchi Slaheddine, Maibach Howard I
Department of Dermatology, School of Medicine, University of California, San Francisco, CA 94143-0989, USA.
Contact Dermatitis. 2007 Jul;57(1):28-34. doi: 10.1111/j.1600-0536.2007.01138.x.
The face showed anatomical variation on reaction to chemicals, which could be related to differences in biophysical specificities of the skin. The aim of this study was to establish a map of the face for 6 biophysical parameters.10 young human volunteers (24-34 years) and 10 old volunteers (66-83 years) were studied to prepare a map of the human face based on regional variations and age-related differences by measuring various biophysical parameters. 7 locations on the face, neck, and forearm were investigated. Skin blood flow, transepidermal water loss (TEWL), stratum corneum hydration (capacitance), temperature, pH, and sebum content of the skin surface were measured. In both groups, skin blood flow in the nose showed the highest value. Perioral and nasolabial areas showed the highest TEWL values. The neck showed the highest capacitance value. The highest skin temperature was detected in the neck in the young group and in the nasolabial area in the old group. The chin showed the most alkaline pH in both groups. Nasolabial area showed the highest sebum content in the young group, as did the chin in the old group. These baseline values provide a framework to build on for ascertaining disease and intervention-related effects.
面部在接触化学物质时表现出解剖学变异，这可能与皮肤生物物理特异性的差异有关。本研究的目的是建立一张包含6项生物物理参数的面部图谱。研究了10名年轻志愿者（24 - 34岁）和10名老年志愿者（66 - 83岁），通过测量各种生物物理参数，根据区域差异和年龄相关差异绘制人类面部图谱。对面部、颈部和前臂的7个部位进行了研究。测量了皮肤血流量、经表皮水分流失（TEWL）、角质层水合作用（电容）、温度、pH值以及皮肤表面的皮脂含量。在两组中，鼻子部位的皮肤血流量最高。口周和鼻唇区域的TEWL值最高。颈部的电容值最高。年轻组中颈部皮肤温度最高，老年组中鼻唇区域皮肤温度最高。两组中下巴部位的pH值最偏碱性。年轻组中鼻唇区域的皮脂含量最高，老年组中下巴部位的皮脂含量最高。这些基线值为确定疾病及与干预相关的影响提供了一个可在此基础上构建的框架。
