Zhou Wei-jun, Tong Jian-jing, Ye Jing, Lu Yi-ming
Department of Emergency, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2007 Jun;19(6):325-8.
To investigate correlation between high sensitivity C-reactive protein (hs-CRP) and risk factors of acute stroke and cerebrovascular disease.
Hs-CRP levels were determined in 118 hypertensive patients with acute stroke (86 patients with cerebral infarction and 32 patients with cerebral hemorrhage) and in 67 healthy volunteers as normal control group by scattered radiation immunoturbidimetry. The difference in hs-CRP was analyzed in these two groups, and the correlation between hs-CRP and the cerebrovascular disease risk factors were analyzed.
Acute stroke patients had a significantly higher level of hs-CRP compared with healthy subjects (P<0.01). There was no significant difference of hs-CRP level between cerebral infarction group and cerebral hemorrhage group. Hs-CRP level was significantly correlated with cerebrovascular accident risks such as age, body mass index (BMI), abdominal circumference, systolic and diastolic pressure, serum total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and serum fasting blood glucose by Pearson correlation analysis (P<0.05 or P<0.01), and strong positive correlations were observed between the hs-CRP level and systolic pressure, the serum fasting blood glucose, total cholesterol, triglycerides, LDL-C and HDL-C by analysis using the multivariate stepwise regression model (all P<0.01).
The high level hs-CRP is in close relation with acute stroke, and blood pressure, serum fasting blood glucose and cholesterol are significant and independent risk factors that might influence the level of hs-CRP.
探讨高敏C反应蛋白（hs-CRP）与急性脑卒中及脑血管疾病危险因素之间的相关性。
采用散射比浊免疫法测定118例急性脑卒中高血压患者（86例脑梗死患者和32例脑出血患者）及67例健康志愿者（作为正常对照组）的hs-CRP水平。分析两组hs-CRP的差异，并分析hs-CRP与脑血管疾病危险因素之间的相关性。
急性脑卒中患者的hs-CRP水平显著高于健康受试者（P<0.01）。脑梗死组和脑出血组的hs-CRP水平无显著差异。通过Pearson相关分析，hs-CRP水平与年龄、体重指数（BMI）、腹围、收缩压和舒张压、血清总胆固醇、甘油三酯、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）及血清空腹血糖等脑血管意外风险显著相关（P<0.05或P<0.01）；多元逐步回归模型分析显示，hs-CRP水平与收缩压、血清空腹血糖、总胆固醇、甘油三酯、LDL-C及HDL-C呈强正相关（均P<0.01）。
hs-CRP高水平与急性脑卒中密切相关，血压、血清空腹血糖和胆固醇是可能影响hs-CRP水平的重要独立危险因素。
