Piché Marie-Eve, Lemieux Simone, Weisnagel Stanley John, Corneau Louise, Nadeau André, Bergeron Jean
Institute of Nutraceuticals and Functional Foods, Québec City, Québec, Canada.
Am J Cardiol. 2005 Jul 1;96(1):92-7. doi: 10.1016/j.amjcard.2005.02.051.
The associations of inflammatory markers (high-sensitivity C-reactive protein [hs-CRP], interleukin-6 [IL-6], tumor necrosis factor-alpha, and fibrinogen) with anthropometric and metabolic variables were examined in a sample of 112 postmenopausal women not receiving hormone therapy. Body fat distribution was measured by computed tomography, and insulin sensitivity was determined by an euglycemic-hyperinsulinemic clamp. hs-CRP (0.10 < or = r(2) < or =0.37) and IL-6 (0.06 < or = r(2) < or =0.31) were significantly associated with anthropometric and metabolic variables, including visceral and subcutaneous adipose tissue, systolic and diastolic blood pressure, triglycerides, high-density lipoprotein (HDL) cholesterol, and insulin sensitivity (p <0.05). Women with greater hs-CRP concentrations showed deterioration in their metabolic risk profiles, including abdominal obesity, greater triglyceride and lower HDL cholesterol concentrations, and lower insulin sensitivity compared with women with lower hs-CRP levels. Fifty-nine percent of women with high hs-CRP concentrations had the metabolic syndrome as recently defined by the Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. After adjustment for visceral adipose tissue, most of the differences in the plasma lipid-lipoprotein profile were eliminated between women with high hs-CRP levels and women with low hs-CRP levels, whereas some differences in blood pressure variables, insulin sensitivity, and inflammatory markers (IL-6 and fibrinogen) remained significant. In conclusion, these results suggest that increased visceral adipose tissue levels appear to be a determinant covariable of the association between high hs-CRP concentrations and alteration in the metabolic profile.
在112名未接受激素治疗的绝经后女性样本中，研究了炎症标志物（高敏C反应蛋白[hs-CRP]、白细胞介素-6[IL-6]、肿瘤坏死因子-α和纤维蛋白原）与人体测量和代谢变量之间的关联。通过计算机断层扫描测量身体脂肪分布，并通过正常血糖-高胰岛素钳夹法测定胰岛素敏感性。hs-CRP（0.10≤r²≤0.37）和IL-6（0.06≤r²≤0.31）与人体测量和代谢变量显著相关，包括内脏和皮下脂肪组织、收缩压和舒张压、甘油三酯、高密度脂蛋白（HDL）胆固醇以及胰岛素敏感性（p<0.05）。与hs-CRP水平较低的女性相比，hs-CRP浓度较高的女性代谢风险状况恶化，包括腹部肥胖、甘油三酯水平较高、HDL胆固醇水平较低以及胰岛素敏感性较低。根据美国国家胆固醇教育计划成人高胆固醇检测、评估和治疗专家小组第三次报告中最近定义的代谢综合征，hs-CRP浓度高的女性中有59%患有该综合征。在对内脏脂肪组织进行调整后，hs-CRP水平高的女性和hs-CRP水平低的女性之间血浆脂质-脂蛋白谱的大部分差异被消除，而血压变量、胰岛素敏感性和炎症标志物（IL-6和纤维蛋白原）的一些差异仍然显著。总之，这些结果表明，内脏脂肪组织水平升高似乎是高hs-CRP浓度与代谢谱改变之间关联的一个决定性协变量。
