Chen Ji-Ming, Chen Ji-Wang, Dai Jian-Jun, Sun Ying-Xue
China Animal Health and Epidemiology Center, Qingdao, China.
Am J Infect Control. 2007 Jun;35(5):351-3. doi: 10.1016/j.ajic.2006.07.016.
H5N1 avian influenza has been widely spreading in fowls in the Eastern Hemisphere and caused hundreds of severe human cases. Here, the information of the 224 human cases of H5N1 avian influenza reported by the World Health Organization before June 2006 were surveyed and analyzed. The results suggested that human infections escalated in the past 3 years, and control of animal H5N1 influenza, avoidance of high-risk behaviors, and proper disposal of diseased or dead fowls are vital for the prevention of the human infections. Age distribution of the human cases demonstrated that older people are more immune to the infection, possibly because of the cross protectivity induced by their previous infections with human influenza A viruses. This survey also suggested that live vaccines against human influenza may be of utility in the prevention of the avian influenza virus infections in humans, and new preventive measures should be considered for the control of animal H5N1 influenza epidemics, which are likely more serious than indicated by official reports.
H5N1禽流感已在东半球的禽类中广泛传播，并导致数百例严重的人类病例。在此，对世界卫生组织在2006年6月之前报告的224例H5N1禽流感人类病例的信息进行了调查和分析。结果表明，在过去3年中人类感染情况有所升级，控制动物H5N1流感、避免高风险行为以及妥善处理患病或死亡禽类对于预防人类感染至关重要。人类病例的年龄分布表明，老年人对感染的免疫力更强，这可能是由于他们先前感染甲型人流感病毒所诱导的交叉保护作用。这项调查还表明，针对人流感的活疫苗可能有助于预防人类感染禽流感病毒，并且应考虑采取新的预防措施来控制动物H5N1流感疫情，这种疫情可能比官方报告显示的更为严重。
