Dong An-Jie, Zhang Jin-Wei, Jiang Kai, Deng Lian-Dong
Department of Polymer Science and Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
J Mater Sci Mater Med. 2008 Jan;19(1):39-46. doi: 10.1007/s10856-007-3166-7. Epub 2007 Jun 19.
Poly(octadecanoic anhydride) (POA) has been prepared by melt polycondensation of octadecanoic diacid. POA was characterized by Fourier-transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) and wide angle X-ray diffraction (WAXD). The results of in vitro degradation and SEM micrographs show that the erosion process of POA is neither bulk nor perfect surface erosion but rather has elements of both in phosphate buffer at 37 degrees C. The moving erosion front is characteristic of surface erosion whereas the remaining porous shell stems from bulk erosion. While a significant special degradation property of POA is that POA presents a very slow degradation rate in acidic condition (pH 5.98), only 1.64% weight loss for 20 days, and it completely degrades after 18 days in basic buffer (pH 7.4). Comparing with poly(sebacic anhydride) (PSA), POA has the higher crystallization degree, and the slower hydrolytic rate.
聚十八烷酸酐（POA）通过十八烷二酸的熔融缩聚反应制备而成。采用傅里叶变换红外光谱（FTIR）、差示扫描量热法（DSC）和广角X射线衍射（WAXD）对POA进行了表征。体外降解结果和扫描电子显微镜（SEM）照片表明，在37℃的磷酸盐缓冲液中，POA的侵蚀过程既不是整体侵蚀也不是完美的表面侵蚀，而是兼具两者的特征。移动的侵蚀前沿是表面侵蚀的特征，而剩余的多孔壳则源于整体侵蚀。POA的一个显著特殊降解特性是，POA在酸性条件（pH 5.98）下呈现出非常缓慢的降解速率，20天内重量损失仅为1.64%，而在碱性缓冲液（pH 7.4）中18天后完全降解。与聚癸二酸酐（PSA）相比，POA具有更高的结晶度和更低的水解速率。
