Jain Jay Prakash, Modi Sweta, Domb A J, Kumar Neeraj
Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Sec. 67, SAS Nagar (Mohalali) Punjab-160062, India.
J Control Release. 2005 Apr 18;103(3):541-63. doi: 10.1016/j.jconrel.2004.12.021.
Many drugs that are administered in an unmodified form by conventional systemic routes fail to reach target organs in an effective concentration, or are not effective over a length of time due to a facile metabolism. Various types of targeting delivery systems and devices have been tried over a long period of time to overcome these problems. Targeted delivery or localized drug delivery offers an advantage of reduced body burden and systemic toxicity of the drugs, especially useful for highly toxic drugs like anticancer agents. Local drug delivery via polymer is a simple approach and hypothesized to avoid the above stated problems. Polyanhydrides are a unique class of polymer for drug delivery because some of them demonstrate a near zero order drug release and relatively rapid biodegradation in vivo. Further, the release rate of polyanhydride fabricated device can be altered over a thousand fold by simple changes in the polymer backbone. Hence, these are one of the best-suited polymers for drug delivery, with biodegradability and biocompatibility. The review focuses on the advantages of polyanhydride carriers in localized drug delivery along with their degradability behavior, toxicological profile and role in various disease conditions.
许多通过传统全身给药途径以未修饰形式给药的药物无法以有效浓度到达靶器官，或者由于代谢过快而在一段时间内无效。长期以来，人们尝试了各种类型的靶向递送系统和装置来克服这些问题。靶向递送或局部药物递送具有减轻药物对身体的负担和全身毒性的优点，这对于像抗癌药物这样的高毒性药物尤其有用。通过聚合物进行局部药物递送是一种简单的方法，并且被认为可以避免上述问题。聚酸酐是一类独特的用于药物递送的聚合物，因为它们中的一些表现出接近零级的药物释放以及在体内相对快速的生物降解。此外，通过简单改变聚合物主链，聚酸酐制成的装置的释放速率可以改变上千倍。因此，这些是最适合用于药物递送的聚合物之一，具有生物可降解性和生物相容性。这篇综述重点介绍了聚酸酐载体在局部药物递送中的优势，以及它们的降解行为、毒理学概况和在各种疾病状态中的作用。
