De Beaumont Louis, Brisson Benoit, Lassonde Maryse, Jolicoeur Pierre
Centre de Recherche en Neuropsychologie et Cognition, Université de Montréal, Montréal, Canada.
Brain Inj. 2007 Jun;21(6):631-44. doi: 10.1080/02699050701426931.
This event-related potentials study investigated the long-term effects associated with a history of one or multiple concussions on the N2pc and P3 components using a visual search oddball paradigm.
A total of 47 university football players were assigned to three experimental groups based on prior concussion history: Athletes with a history of one concussion (single-concussion group); Athletes with two or more concussions (multi-concussion group); non-concussed athletic controls. The average post-concussion period was 31 months for athletes in the multi-concussion group and 59 months for the single-concussion group.
This study found significantly suppressed P3 amplitude in the multi-concussed athletes group compared to the single-concussion and non-concussed athletes even when using the time since the latest concussion as a covariate.
This finding suggests that the multi-concussed athletes group showed long-lasting P3 amplitude suppression when compared with single-concussion or non-concussed athletes despite equivalent neuropsychological test scores and post-concussion symptoms self-reports. This pattern of results is important because it shows that 'old' concussions do not cause general or ubiquitous electrophysiological suppression. The specificity of the long-term effects of previous concussions to the P3, along with an intact N2pc response, suggests that further work may allow one to pinpoint the cognitive system that is specifically affected by multiple concussions.
本事件相关电位研究使用视觉搜索奇偶数范式，调查了有一次或多次脑震荡病史与N2pc和P3成分相关的长期影响。
根据既往脑震荡病史，将47名大学橄榄球运动员分为三个实验组：有一次脑震荡病史的运动员（单次脑震荡组）；有两次或更多次脑震荡病史的运动员（多次脑震荡组）；未发生脑震荡的运动对照组。多次脑震荡组运动员的平均脑震荡后时间为31个月，单次脑震荡组为59个月。
本研究发现，即使将距最近一次脑震荡的时间作为协变量，多次脑震荡运动员组的P3波幅与单次脑震荡和未发生脑震荡的运动员相比仍显著受到抑制。
这一发现表明，尽管多次脑震荡运动员组在神经心理测试得分和脑震荡后症状自我报告方面与单次脑震荡或未发生脑震荡的运动员相当，但与他们相比，多次脑震荡运动员组表现出持久的P3波幅抑制。这种结果模式很重要，因为它表明“陈旧性”脑震荡不会导致普遍或无处不在的电生理抑制。既往脑震荡对P3的长期影响具有特异性，同时N2pc反应完整，这表明进一步的研究可能有助于确定受多次脑震荡特异性影响的认知系统。
