多重用药与处方不足之间的关系。
Relationship between polypharmacy and underprescribing.
作者信息
Kuijpers Mascha A J, van Marum Rob J, Egberts Antoine C G, Jansen Paul A F
机构信息
Department of Geriatric Medicine, University Medical Centre, Utrecht, the Netherlands.
出版信息
Br J Clin Pharmacol. 2008 Jan;65(1):130-3. doi: 10.1111/j.1365-2125.2007.02961.x. Epub 2007 Jun 19.
AIMS
Underprescribing is increasingly recognized as an important problem. The aim of this study was to determine the relationship between polypharmacy and underprescribing.
METHODS
Treatment of current medical problems in geriatric patients was compared with general practitioner and national guidelines. Underprescription was defined as lack of an indicated drug, while no reason could be found for not prescribing it. Polypharmacy was defined as five or more drugs.
RESULTS
Polypharmacy was present in 61% of 150 patients. Underprescription was found in 47 (31%). Of patients with polypharmacy 42.9% were undertreated, in contrast to 13.5% of patients using four medicines or less (OR 4.8, 95% CI 2.0, 11.2). The estimated probability of underprescription increased significantly with the number of drugs.
CONCLUSIONS
We found a clear relationship between polypharmacy and underprescribing.
目的
用药不足日益被视为一个重要问题。本研究的目的是确定多重用药与用药不足之间的关系。
方法
将老年患者当前医疗问题的治疗情况与全科医生及国家指南进行比较。用药不足被定义为缺乏一种已指明的药物，且找不到不开药的理由。多重用药被定义为使用五种或更多药物。
结果
150名患者中有61%存在多重用药情况。发现47名患者（31%）用药不足。在多重用药的患者中，42.9%的患者治疗不足，而使用四种或更少药物的患者中这一比例为13.5%（比值比4.8，95%可信区间2.0，11.2）。用药不足的估计概率随着药物数量的增加而显著增加。
结论
我们发现多重用药与用药不足之间存在明显关系。
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