Ward P E, Gedney C D, Dowben R M, Erdös E G
Biochem J. 1975 Dec;151(3):755-8. doi: 10.1042/bj1510755.
Fractions highly enriched in plasma membrane, endoplasmic reticulum or brush border were prepared from homogenized rat kidney cortex. Kallikrein was concentrated in the plasma-membrane fraction, but not in the brush border of the proximal tubules. Kininase II or angiotensin I-converting enzyme was localized in the brush-border membrane. It is suggested that kallikrein in the urine may originate from the plasma membrane of the distal tubules and the conversion of angiotensin I and the inactivation of bradykinin may occur on the lumen membrane of the proximal tubular cells.
从匀浆的大鼠肾皮质中制备出高度富集于质膜、内质网或刷状缘的组分。激肽释放酶集中在质膜组分中，而不在近端小管的刷状缘中。激肽酶II或血管紧张素I转换酶定位于刷状缘膜中。提示尿中的激肽释放酶可能起源于远端小管的质膜，血管紧张素I的转换和缓激肽的失活可能发生在近端小管细胞的管腔膜上。
