大鼠中含有激肽释放酶、血管紧张素I转换酶（激肽酶II）和血管紧张素酶的肾膜的分离。

Isolation of renal membranes that contain kallikrein, angiotensin I-converting enzyme (kininase II) and angiotensinase in the rat.

Ward P E, Erdös E G, Gedney C D, Dowben R M, Reynolds R C

Clin Sci Mol Med Suppl. 1976 Dec;3:267s-270s. doi: 10.1042/cs051267s.

Abstract

Fractions highly enriched in plasma membrane, endoplasmic reticulum or brush border were prepared from rat kidney cortex. Kallikrein was concentrated in the plasma membrane fraction, but not in the brush border fraction. Angiotensin I-converting enzyme (kininase II) and angiotensinase were localized in the brush border membrane. 2. It is suggested that kallikrein in the urine may originate from plasma membrane distal to the brush border of proximal tubules and the conversion of angiotensin I and the inactivation of bradykinin and angiotensin II may occur on the lumen membrane of the proximal tubular cells.

摘要

从大鼠肾皮质制备了高度富集于质膜、内质网或刷状缘的组分。激肽释放酶集中在质膜组分中，而不在刷状缘组分中。血管紧张素I转换酶（激肽酶II）和血管紧张素酶定位于刷状缘膜。2. 提示尿中的激肽释放酶可能起源于近端小管刷状缘远端的质膜，并且血管紧张素I的转化以及缓激肽和血管紧张素II的失活可能发生在近端小管细胞的管腔膜上。