脑源性神经营养因子Val(66)Met×5-羟色胺转运体基因连锁多态性区域×儿童逆境交互作用与抑郁症状：一项复制研究尝试
The BDNF Val(66)Met x 5-HTTLPR x child adversity interaction and depressive symptoms: An attempt at replication.
作者信息
Wichers Marieke, Kenis Gunter, Jacobs Nele, Mengelers Ron, Derom Catherine, Vlietinck Robert, van Os Jim
机构信息
Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands.
出版信息
Am J Med Genet B Neuropsychiatr Genet. 2008 Jan 5;147B(1):120-3. doi: 10.1002/ajmg.b.30576.
Kaufman et al. [2006] reported a higher order interaction effect between specific genetic and environmental factors in a model of depressive symptoms, requiring independent replication. BDNF Val(66)Met and 5-HTTLPR genotypes were determined in female participants pertaining to a large ongoing twin study. Participants also filled in questionnaires on childhood adversity and depressive symptoms. Two- and three-way interactions between genetic polymorphisms and early adversity were examined in models of depressive symptoms. BDNF Met allele(s) moderated the effect of early adversity on depressive symptoms (two-way interaction), and this BDNF Met x childhood adversity interaction in turn was moderated by 5-HTTLPR genotype (three-way interaction). However, a main effect of BDNF Met on childhood adversity was also observed, possibly indicating confounding by gene-environment correlation. Higher order interaction effects involving BDNF Val(66)Met, 5-HTTLPR and childhood adversity may contribute to the etiology of depressive illness.
考夫曼等人[2006年]报告称，在一个抑郁症状模型中，特定基因和环境因素之间存在高阶交互效应，这需要独立重复验证。在一项正在进行的大型双胞胎研究的女性参与者中确定了脑源性神经营养因子（BDNF）Val(66)Met和5-羟色胺转运体基因启动子区域（5-HTTLPR）的基因型。参与者还填写了关于童年逆境和抑郁症状的问卷。在抑郁症状模型中研究了基因多态性与早期逆境之间的二阶和三阶交互作用。BDNF Met等位基因调节了早期逆境对抑郁症状的影响（二阶交互作用），而这种BDNF Met与童年逆境的交互作用又受到5-HTTLPR基因型的调节（三阶交互作用）。然而，也观察到BDNF Met对童年逆境的主效应，这可能表明存在基因-环境相关性的混杂因素。涉及BDNF Val(66)Met、5-HTTLPR和童年逆境的高阶交互效应可能有助于解释抑郁症的病因。
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