用于药物靶向的基于间苯二酚芳烃的自组装固体脂质纳米粒的表面修饰

Surface modification of resorcinarene based self-assembled solid lipid nanoparticles for drug targeting.

作者信息

Ehrler Stefan, Pieles Uwe, Wirth-Heller Amina, Shahgaldian Patrick

机构信息

University of Applied Sciences Northwestern Switzerland, School of Life Sciences, Institute of Chemistry and Bioanalytics, Gründenstrasse 40, 4132 Muttenz, Switzerland.

出版信息

Chem Commun (Camb). 2007 Jul 7(25):2605-7. doi: 10.1039/b703106h. Epub 2007 Apr 13.

DOI:10.1039/b703106h

PMID:17579752

Abstract

Prolyl-bearing amphiphilic resorcinarenes, e.g. tetrakis(N-methylprolyl)tetraundecylcalix[4]resorcinarene, self-assemble as stable solid lipid nanoparticles; these fully characterized systems could be further functionalized at their surface with proteins, and interact with specific antibodies bound on a sensor surface.

摘要

含脯氨酰的两亲性间苯二酚杯芳烃，例如四（N-甲基脯氨酰）四十一烷基杯[4]间苯二酚杯芳烃，可自组装形成稳定的固体脂质纳米颗粒；这些经过充分表征的体系可在其表面进一步用蛋白质进行功能化，并与结合在传感器表面的特异性抗体相互作用。