El-Ansary Afaf K, Al Daihan Soad K
Department of Biochemistry, College of Science, King Saud University, P.O Box 22452, Riyadh 11495, Saudi Arabia.
J Egypt Soc Parasitol. 2007 Apr;37(1):39-50.
Schistosomes have a complex lifecycle with freshwater intermediate host snails. The snail host represents the weakest point in the lifecycle of parasite. Biomphalaria arabica is intermediate host for Schistosoma mansoni in Saudi Arabia. In this work, aspartate and alanine aminotransferases (AST and ALT) and lactate dehydrogenase (LDH) were measured in the tissue homogenate and haemolymph of B. arabica. Besides, the effect of sublethal concentrations (LC25) of dry powdered Solanum nigrum leaf was tested as plant molluscicide against B. arabica. The studied enzymes were altered in molluscicide-treated snails compared to control. AST and ALT were slightly affected but LDH was the most significantly altered enzyme. The role of the biochemical manipulation in affecting host-parasite relationship was discussed.
血吸虫与淡水中间宿主蜗牛有着复杂的生命周期。蜗牛宿主是寄生虫生命周期中最薄弱的环节。阿拉伯双脐螺是沙特阿拉伯曼氏血吸虫的中间宿主。在这项研究中，对阿拉伯双脐螺的组织匀浆和血淋巴中的天冬氨酸转氨酶和丙氨酸转氨酶（AST和ALT）以及乳酸脱氢酶（LDH）进行了测定。此外，还测试了龙葵叶干粉的亚致死浓度（LC25）作为植物杀螺剂对阿拉伯双脐螺的影响。与对照组相比，经杀螺剂处理的蜗牛体内所研究的酶发生了变化。AST和ALT受到的影响较小，但LDH是变化最显著的酶。文中还讨论了生化调控在影响宿主 - 寄生虫关系方面的作用。
