Al-Daihan Sooad
Department of Biochemistry, Science College, King Saud University, PO Box 22452, Zip code 11495, Saudi Arabia.
J Egypt Soc Parasitol. 2010 Apr;40(1):187-95.
Schistosomiasis is one of the most important human parasitic diseases. One of the possible methods for the control is through the molluscan intermediate host of the parasite. Biomphalaria arabica, molluscan hosts to Schistosoma mansoni in Saudi Arabia were treated with sublethal concentrations (LC25) of dry powdered leaves Solanum nigrum. Effect of plant on ectonucleotidases (NTPdases) (ADPase & ATPase), sodium/potassium adenosine triphosphatase (Na+/K+ ATPase) and creatine kinase (CK) was traced. The plant molluscicide was potent in inhibiting the four investigated enzymes giving a percentage inhibition range between 45-55%. The effect of the inhibited enzymes on the compatibility of the snail hosts to schistosome parasite was discussed. In conclusion, the use of sublethal concentration of S. nigrum to disturb the biochemical profile of the snail hosts could be a promising and safe strategy to control the disease.
血吸虫病是最重要的人类寄生虫病之一。控制该病的一种可能方法是通过寄生虫的软体动物中间宿主。阿拉伯双脐螺是沙特阿拉伯曼氏血吸虫的软体动物宿主，用亚致死浓度（LC25）的龙葵干叶粉末进行处理。追踪了该植物对胞外核苷酸酶（NTPdases）（ADP酶和ATP酶）、钠/钾腺苷三磷酸酶（Na+/K+ATP酶）和肌酸激酶（CK）的影响。该植物杀螺剂对所研究的四种酶具有很强的抑制作用，抑制率在45%-55%之间。讨论了被抑制的酶对蜗牛宿主与血吸虫寄生虫相容性的影响。总之，使用亚致死浓度的龙葵来扰乱蜗牛宿主的生化特征可能是控制该病的一种有前景且安全的策略。
