特发性快速眼动睡眠行为障碍患者血清性激素水平无改变。
Absence of alterations in serum sex hormone levels in idiopathic REM sleep behavior disorder.
作者信息
Iranzo Alex, Santamaría Joan, Vilaseca Isabel, de Osaba Maria Jesús Martínez
机构信息
Neurology Service, Hospital Clinic and Institut D'Investigació Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
出版信息
Sleep. 2007 Jun;30(6):803-6. doi: 10.1093/sleep/30.6.803.
Abstract
STUDY OBJECTIVES
More than 85% of the patients presenting to sleep centers with idiopathic REM sleep behavior disorder (RBD) are men. It has been hypothesized that sex hormone abnormalities may be related to this male predominance. The aim of our study was to determine the serum sex hormone levels in consecutive idiopathic RBD male patients who presented to our sleep center.
SETTING
University hospital sleep disorders center.
PARTICIPANTS
Fourteen male idiopathic RBD patients and 16 healthy matched controls.
INTERVENTIONS
NA.
MEASUREMENTS AND RESULTS
Serum levels of total testosterone, calculated free testosterone, calculated bioavailable testosterone, luteinizing hormone, follicle stimulating hormone, estradiol-17 beta, sex-hormone binding globulin, and prolactin were not different between idiopathic RBD patients and controls.
CONCLUSION
Serum sex hormone levels are normal in idiopathic RBD, indicating that androgenic abnormalities may not account for its male predominance and pathophysiology.
摘要
研究目的
前往睡眠中心就诊的特发性快速眼动睡眠行为障碍（RBD）患者中，超过85%为男性。据推测，性激素异常可能与这种男性主导现象有关。我们研究的目的是测定连续就诊于我们睡眠中心的特发性RBD男性患者的血清性激素水平。
研究地点
大学医院睡眠障碍中心。
研究对象
14名男性特发性RBD患者和16名健康对照者，两者相匹配。
干预措施
无。
测量指标与结果
特发性RBD患者与对照组之间，血清总睾酮、计算得出的游离睾酮、计算得出的生物可利用睾酮、促黄体生成素、促卵泡生成素、雌二醇-17β、性激素结合球蛋白和催乳素水平并无差异。
结论
特发性RBD患者的血清性激素水平正常，这表明雄激素异常可能无法解释其男性主导现象及病理生理机制。
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