费歇尔卡宾配合物的分子内环己二烯酮环化反应：光活菌素合成的模型研究
Intramolecular cyclohexadienone annulations of Fischer carbene complexes: model studies for the synthesis of Phomactins.
作者信息
Huang Jie, Wang Huan, Wu Chunrui, Wulff William D
机构信息
Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, USA.
出版信息
Org Lett. 2007 Jul 19;9(15):2799-802. doi: 10.1021/ol070904q. Epub 2007 Jun 20.
Abstract
The intramolecular cyclohexadienone annulation of chromium carbene complexes is examined as a method to provide general access to the Phomactin family of natural products. The importance of the stereochemistry of the carbene complex and the number of carbons in the tether connecting the carbene complex and the alkyne are probed. Additionally, the degree of the 1,4-asymmetric induction is examined.
摘要
研究了铬卡宾配合物的分子内环己二烯酮环化反应，作为一种普遍获得天然产物佛马菌素家族的方法。探讨了卡宾配合物立体化学的重要性以及连接卡宾配合物与炔烃的系链中的碳原子数。此外，还研究了1,4-不对称诱导程度。
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