合成在远端和近端位点均带有关键成分的一氧化氮还原酶活性位点模型。
Synthesis of nitric oxide reductase active site models bearing key components at both distal and proximal sites.
作者信息
Collman James P, Yang Ying, Decréau Richard A
机构信息
Department of Chemistry, Stanford University, Stanford, California 94305-5080, USA.
出版信息
Org Lett. 2007 Jul 19;9(15):2855-8. doi: 10.1021/ol071007p. Epub 2007 Jun 20.
Abstract
Porphyrins 1ab and 2ab were successfully synthesized from cis-alpha2-bisimidazole-beta-imidazole-tail porphyrins and two newly synthesized imidazole pickets containing an aliphatic ester chain following a [2+1] approach. The four compounds possess a distal trisimidazole set, a distal carboxylic acid, and a proximal imidazole, which constitute all the key features of the coordination environment of the active site in Bacterial Nitric Oxide Reductase (NOR) and make them the closest synthetic NOR model ligands to date.
摘要
卟啉1ab和2ab由顺式-α2-双咪唑-β-咪唑-尾卟啉和两条新合成的含脂肪族酯链的咪唑探针按照[2+1]方法成功合成。这四种化合物具有一个远端三咪唑基团、一个远端羧酸基团和一个近端咪唑基团，这些构成了细菌一氧化氮还原酶（NOR）活性位点配位环境的所有关键特征，使它们成为迄今为止最接近的合成NOR模型配体。
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