含三咪唑和戊二酸的卟啉的高效合成：用于细菌一氧化氮还原酶活性位点模型的配体
Efficient synthesis of trisimidazole and glutaric acid bearing porphyrins: ligands for active-site models of bacterial nitric oxide reductase.
作者信息
Collman James P, Yan Yi-Long, Lei Jianping, Dinolfo Peter H
机构信息
Department of Chemistry, Stanford University, California 94305-5080, USA.
出版信息
Org Lett. 2006 Mar 2;8(5):923-6. doi: 10.1021/ol053118z.
Abstract
Ligands (1) for active-site models of bacterial nitric oxide reductase (NOR) have been efficiently synthesized. These compounds (1) feature three imidazolyl moieties and one carboxylic acid residue at the FeB site, which represent the closest available synthetic model ligands of NOR active center. The stereo conformations of these ligands are established on the basis of steric effects and 1H NMR chemical shifts under the ring current effect of the porphyrin.
摘要
已高效合成了用于细菌一氧化氮还原酶（NOR）活性位点模型的配体（1）。这些化合物（1）在FeB位点具有三个咪唑基部分和一个羧酸残基，它们是NOR活性中心最接近的可用合成模型配体。这些配体的立体构象是基于卟啉环电流效应下的空间效应和1H NMR化学位移确定的。
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