通过钯催化的烷基硼烷与碳酰氯的偶联实现烯烃的一锅法酰胺化反应。
One-pot amidation of olefins through Pd-catalyzed coupling of alkylboranes and carbamoyl chlorides.
作者信息
Yasui Yoshizumi, Tsuchida Sayo, Miyabe Hideto, Takemoto Yoshiji
机构信息
Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan.
出版信息
J Org Chem. 2007 Jul 20;72(15):5898-900. doi: 10.1021/jo070724u. Epub 2007 Jun 20.
PMID:17580905
Abstract
A one-pot synthesis of C1-elongated amides starting from olefins and carbamoyl chlorides has been developed. Alkylboranes, generated by hydroboration of terminal olefins with 9-BBN-H, underwent smooth coupling with carbamoyl chlorides in the presence of palladium catalyst and Cs2CO3.
摘要
已开发出一种从烯烃和碳酰氯开始一锅法合成C1-延长酰胺的方法。通过用9-BBN-H对末端烯烃进行硼氢化反应生成的烷基硼烷，在钯催化剂和碳酸铯存在下与碳酰氯顺利偶联。
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