Yasui Yoshizumi, Tsuchida Sayo, Miyabe Hideto, Takemoto Yoshiji
Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan.
J Org Chem. 2007 Jul 20;72(15):5898-900. doi: 10.1021/jo070724u. Epub 2007 Jun 20.
A one-pot synthesis of C1-elongated amides starting from olefins and carbamoyl chlorides has been developed. Alkylboranes, generated by hydroboration of terminal olefins with 9-BBN-H, underwent smooth coupling with carbamoyl chlorides in the presence of palladium catalyst and Cs2CO3.
已开发出一种从烯烃和碳酰氯开始一锅法合成C1-延长酰胺的方法。通过用9-BBN-H对末端烯烃进行硼氢化反应生成的烷基硼烷，在钯催化剂和碳酸铯存在下与碳酰氯顺利偶联。
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