Li Shi-hong, Xing Yan-wei, Li Zhi-zhong, Bai Shu-gong, Wang Jie
Emergency Center, Beijing Anzhen Hospital, Capital University of Medical Science, Beijing 100029, China.
Zhonghua Xin Xue Guan Bing Za Zhi. 2007 Mar;35(3):241-4.
To investigate the clinical implications of relationship between myeloperoxidase and acute coronary syndromes (ACS).
176 consecutive patients who underwent coronary angiography for coronary atherosclerosis were divided into four groups according to the quartile of MPO Level. The characters and the relationship between MPO and the elements were studied in every group.
(1) ACS rate (36.2%) in the fourth quartile group of MPO level was 6 times higher than that (5.2%) in the first quartile group of MPO level, P < 0.01. (2) Gensini score (65.6 +/- 30.3) in the fourth quartile group of MPO level was significantly higher than that (17.3 +/- 10.2) in the first quartile group (P < 0.01). WBC [(7.7 +/- 1.6) x 10(9)/L] in the fourth quartile group was also significantly higher than that [(6.6 +/- 1.8) x 10(9)/L] in the first quartile group, P < 0.05. (3) When TnI < or = 0.05 ng/ml, MPO level had a positive correlation with Gensini score (r = 0.321, P = 0.002) and WBC (r = 0.230, P = 0.025). (4) Kaplan-meier event rate curve showed that there was a significant difference of the terminus incident (death, no causing death AMI, vessel reestablish and incidence rate of CABG add up) between the groups > or = 62.9 AUU/L and < 62.9 AUU/L of MPO serum level at 6-month follow-up visit (chi(2) = 13.5, P = 0.01).
Activity level of MPO in human serum seems a good biomarker for diagnosing and predicting ACS, which may be especially helpful in predicting the risk of myocardial infarction in patients with acute chest pain during 6-month follow up.
探讨髓过氧化物酶与急性冠状动脉综合征（ACS）之间关系的临床意义。
176例因冠状动脉粥样硬化接受冠状动脉造影的连续患者，根据髓过氧化物酶（MPO）水平的四分位数分为四组。研究每组的特征以及MPO与各因素之间的关系。
（1）MPO水平第四四分位数组的ACS发生率（36.2%）比MPO水平第一四分位数组的发生率（5.2%）高6倍，P<0.01。（2）MPO水平第四四分位数组的Gensini评分（65.6±30.3）显著高于第一四分位数组（17.3±10.2）（P<0.01）。第四四分位数组的白细胞计数[（7.7±1.6）×10⁹/L]也显著高于第一四分位数组[（6.6±1.8）×10⁹/L]，P<0.05。（3）当肌钙蛋白I（TnI）≤0.05 ng/ml时，MPO水平与Gensini评分（r = 0.321，P = 0.002）和白细胞（r = 0.230，P = 0.025）呈正相关。（4）Kaplan-meier事件发生率曲线显示，在6个月随访时，MPO血清水平≥62.9 AUU/L组和<62.9 AUU/L组之间的终点事件（死亡、非致死性急性心肌梗死、血管重建以及冠状动脉旁路移植术发生率总和）存在显著差异（χ² = 13.5，P = 0.01）。
人血清中MPO的活性水平似乎是诊断和预测ACS的良好生物标志物，这可能对预测急性胸痛患者在6个月随访期间发生心肌梗死的风险特别有帮助。
