人类孵化囊胚的玻璃化冷冻：4例报告
Vitrification of human hatched blastocysts: a report of 4 cases.
作者信息
Hiraoka Kenichiro, Hiraoka Kaori, Kinutani Masayuki, Kinutani Kazuo
机构信息
Kinutani Women's Clinic, 2-1-4-3F, Ohtemachi, Naka-ku, Hiroshima 730-0051, Japan.
出版信息
J Reprod Med. 2007 May;52(5):413-5.
BACKGROUND
Vitrification is a fairly well-established technique for cryopreservation of human zona-intact blastocysts. However, little is known about the efficacy of the vitrification technique for zona-free hatched blastocysts.
CASE
A total of 4 hatched blastocysts from 4 healthy, infertile women undergoing in vitro fertilization were vitrified and warmed. All 4 hatched blastocysts expanded after warming and were transferred to 4 patients. Three of the women became clinically pregnant. Two healthy infants were born in 2 deliveries, and 1 pregnancy had progressed to 35 weeks at this writing.
CONCLUSION
Our results suggest that vitrification is a useful cryopreservation technique not only for zona-intact blastocysts but also for zona-free hatched blastocysts.
背景
玻璃化冷冻是一种成熟的人类完整透明带囊胚冷冻保存技术。然而，对于无透明带孵化囊胚的玻璃化冷冻技术效果知之甚少。
病例
对4例接受体外受精的健康不孕妇女的4枚孵化囊胚进行玻璃化冷冻及解冻。4枚孵化囊胚解冻后均膨胀，并移植给4例患者。其中3例妇女临床妊娠。2次分娩中诞下2名健康婴儿，截至撰写本文时，1例妊娠已进展至35周。
结论
我们的结果表明，玻璃化冷冻不仅是一种用于完整透明带囊胚的有用冷冻保存技术，也是用于无透明带孵化囊胚的有用技术。
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