腺病毒载体生物学与靶向性的当前进展及未来挑战
Current advances and future challenges in Adenoviral vector biology and targeting.
作者信息
Campos Samuel K, Barry Michael A
机构信息
Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA.
出版信息
Curr Gene Ther. 2007 Jun;7(3):189-204. doi: 10.2174/156652307780859062.
Gene delivery vectors based on Adenoviral (Ad) vectors have enormous potential for the treatment of both hereditary and acquired disease. Detailed structural analysis of the Ad virion, combined with functional studies has broadened our knowledge of the structure/function relationships between Ad vectors and host cells/tissues and substantial achievement has been made towards a thorough understanding of the biology of Ad vectors. The widespread use of Ad vectors for clinical gene therapy is compromised by their inherent immunogenicity. The generation of safer and more effective Ad vectors, targeted to the site of disease, has therefore become a great ambition in the field of Ad vector development. This review provides a synopsis of the structure/function relationships between Ad vectors and host systems and summarizes the many innovative approaches towards achieving Ad vector targeting.
基于腺病毒（Ad）载体的基因递送载体在治疗遗传性疾病和后天性疾病方面具有巨大潜力。对腺病毒病毒粒子进行详细的结构分析，并结合功能研究，拓宽了我们对腺病毒载体与宿主细胞/组织之间结构/功能关系的认识，在全面理解腺病毒载体生物学方面取得了重大进展。腺病毒载体因其固有的免疫原性，限制了其在临床基因治疗中的广泛应用。因此，开发更安全、更有效的靶向疾病部位的腺病毒载体，已成为腺病毒载体研发领域的一大目标。本综述概述了腺病毒载体与宿主系统之间的结构/功能关系，并总结了实现腺病毒载体靶向的多种创新方法。
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