靶向腺病毒用于治疗应用和疫苗。
Retargeting adenoviruses for therapeutic applications and vaccines.
机构信息
Department of Medicine, Division of Infectious Diseases, Department of Immunology, Department of Molecular Medicine, Mayo Clinic, Rochester, MN, USA.
Virology and Gene Therapy Graduate Program, Mayo Graduate School, Mayo Clinic, Rochester, MN, USA.
出版信息
FEBS Lett. 2020 Jun;594(12):1918-1946. doi: 10.1002/1873-3468.13731. Epub 2020 Feb 3.
Abstract
Adenoviruses (Ads) are robust vectors for therapeutic applications and vaccines, but their use can be limited by differences in their in vitro and in vivo pharmacologies. This review emphasizes that there is not just one Ad, but a whole virome of diverse viruses that can be used as therapeutics. It discusses that true vector targeting involves not only retargeting viruses, but importantly also detargeting the viruses from off-target cells.
摘要
腺病毒（Ads）是治疗应用和疫苗的强大载体，但由于其在体外和体内的药理学差异，其使用可能会受到限制。这篇综述强调，可供治疗使用的并不只有一种腺病毒，而是一整个多样化病毒的病毒组。它还讨论了真正的载体靶向不仅涉及重新靶向病毒，而且还涉及将病毒从非靶细胞中去除靶向。
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