Kelly J B, Payne R
Department of Neurology, University of Cincinnati College of Medicine, Ohio.
Neurol Clin. 1991 Nov;9(4):937-53.
Paraneoplastic syndromes affect the nervous system in a very small percentage of patients with cancer. In those patients, portions of the nervous system are damaged or destroyed, usually in association with a small and often occult neoplasm elsewhere in the body. Current evidence suggests that these syndromes occur when the body mounts an immune response to an antigen shared between the tumor and the nervous system. The immune attack is then misdirected against that portion of the nervous system that possesses the "onconeural" antigen.
副肿瘤综合征仅在极少数癌症患者中影响神经系统。在这些患者中，神经系统的某些部分受损或被破坏，通常与身体其他部位一个小的且往往隐匿的肿瘤有关。目前的证据表明，当身体对肿瘤和神经系统共有的一种抗原产生免疫反应时，就会发生这些综合征。然后，免疫攻击被错误地导向拥有“肿瘤神经”抗原的那部分神经系统。
