Darnell Robert B, Posner Jerome B
Howard Hughes Medical Institute and Laboratory of Molecular Neuro-Oncology, The Rockefeller University, New York, NY 10021, USA.
Semin Oncol. 2006 Jun;33(3):270-98. doi: 10.1053/j.seminoncol.2006.03.008.
The paraneoplastic neurologic disorders (PND) are a diverse group of diseases characterized by the presence of neurologic dysfunction in the setting of a remote cancer. PND can affect almost any part of the nervous system, and are most commonly associated with lung cancer (small cell) and gynecologic tumors. Laboratory studies have demonstrated that an autoimmune response links the neurologic disorder and the cancer, and established a model whereby the cancer is believed to initiate the syndrome by expressing a protein antigen normally expressed in the nervous system, leading to anti-tumor immune response followed by autoimmune neurologic symptoms. We review the currently known PND and their pathogenesis.
副肿瘤性神经系统疾病（PND）是一组多样的疾病，其特征是在远处存在癌症的情况下出现神经功能障碍。PND可影响神经系统的几乎任何部位，最常与肺癌（小细胞癌）和妇科肿瘤相关。实验室研究表明，自身免疫反应将神经疾病与癌症联系起来，并建立了一个模型，据此认为癌症通过表达一种通常在神经系统中表达的蛋白质抗原引发该综合征，导致抗肿瘤免疫反应，随后出现自身免疫性神经症状。我们综述了目前已知的PND及其发病机制。
