Boros Peter, Liu Jianhua, Li Yansui, Bromberg Jonathan S
Microvascular Surgery, Shared Research Facilities, Mount Sinai School of Medicine, New York, NY 10029, United States.
Transpl Immunol. 2007 Jul;18(1):44-52. doi: 10.1016/j.trim.2007.03.004. Epub 2007 Apr 9.
Rodent models of solid organ transplantation have been used for many decades. Standardized operative techniques resulting in highly reproducible survival rates have been developed for several organs. This allowed scientists to investigate many clinically relevant problems, test new drugs and establish novel treatment regimens. Recently, many studies used these models to explore novel issues such as graft modification by pharmaceutical, surgical or genetic engineering methods, post-transplant regeneration, leukocyte trafficking or interactions between the innate and allo-specific arms of the immune response. The results from these studies clearly facilitate a more complex and comprehensive understanding of existing problem. The long-established methods of rodent organ transplantation, combined with the newest achievements in surgical techniques, biotechnology and imaging, will remain indispensable tools of transplantation biology.
实体器官移植的啮齿动物模型已经使用了数十年。针对多个器官，已经开发出了能产生高度可重复存活率的标准化手术技术。这使得科学家能够研究许多临床相关问题、测试新药并建立新的治疗方案。最近，许多研究使用这些模型来探索新问题，如通过药物、手术或基因工程方法对移植物进行改造、移植后再生、白细胞迁移或免疫反应的天然免疫和同种异体特异性免疫分支之间的相互作用。这些研究结果显然有助于更复杂、更全面地理解现有问题。长期以来建立的啮齿动物器官移植方法，结合手术技术、生物技术和成像方面的最新成果，仍将是移植生物学不可或缺的工具。
