Medical School, University of Western Australia, Perth, WA 6009, Australia; School of Human Sciences, University of Western Australia, Perth, WA 6009, Australia.
Medical School, University of Western Australia, Perth, WA 6009, Australia; Western Australian Liver and Kidney Transplant Service, Sir Charles Gairdner Hospital, Perth, WA 6009, Australia.
Cell Rep. 2021 May 18;35(7):109141. doi: 10.1016/j.celrep.2021.109141.
The heterogeneous pool of tissue-resident lymphocytes in solid organs mediates infection responses and supports tissue integrity and repair. Their vital functions in normal physiology suggest an important role in solid organ transplantation; however, their detailed examination in this context has not been performed. Here, we report the fate of multiple lymphocyte subsets, including T, B, and innate lymphoid cells, after murine liver and heart transplantation. In major histocompatibility complex (MHC)-matched transplantation, donor lymphocytes are retained in liver grafts and peripheral lymphoid organs of heart and liver transplant recipients. In MHC-mismatched transplantation, increased infiltration of the graft by recipient cells and depletion of donor lymphocytes occur, which can be prevented by removal of recipient T and B cells. Recipient lymphocytes fail to recreate the native organs' phenotypically diverse tissue-resident lymphocyte composition, even in MHC-matched models. These post-transplant changes may leave grafts vulnerable to infection and impair long-term graft function.
实体器官中组织驻留淋巴细胞的异质群体介导感染反应，并支持组织完整性和修复。它们在正常生理中的重要功能表明它们在实体器官移植中具有重要作用；然而，在这种情况下，尚未对其进行详细检查。在这里，我们报告了多种淋巴细胞亚群（包括 T 细胞、B 细胞和固有淋巴细胞）在小鼠肝和心脏移植后的命运。在主要组织相容性复合体 (MHC) 匹配的移植中，供体淋巴细胞保留在肝移植物和心脏和肝脏移植受者的外周淋巴器官中。在 MHC 不匹配的移植中，受者细胞会更多地浸润移植物，而供体淋巴细胞则会耗竭，这可以通过去除受者 T 和 B 细胞来预防。受者淋巴细胞无法在 MHC 匹配的模型中重新形成具有表型多样性的固有器官驻留淋巴细胞组成。这些移植后的变化可能使移植物容易受到感染并损害长期移植物功能。
