Su D H W, Friedman D S, See J L S, Chew P T K, Chan Y-H, Nolan W P, Smith S D, Huang D, Zheng C, Li Y, Foster P J, Aung T
Singapore National Eye Centre, 11 Third Hospital Avenue, Singapore 168751.
Br J Ophthalmol. 2008 Jan;92(1):103-7. doi: 10.1136/bjo.2007.122572. Epub 2007 Jun 21.
To evaluate the relationship between angle width as determined by anterior segment optical coherence tomography (AS-OCT) and the presence of peripheral anterior synechiae (PAS).
This was a prospective observational case series in which 203 subjects with primary angle closure or open angles were recruited. Images of the nasal, temporal and inferior angles were obtained with AS-OCT in dark conditions. Subjects then underwent gonioscopy by an independent examiner who was masked to the AS-OCT findings. PAS were identified by gonioscopy and defined as abnormal adhesions of the iris to the angle that were at least half a clock hour in width and present to the level of the anterior trabecular meshwork or higher. The total clock hours of PAS were recorded.
Sixty-eight subjects (33.5%) were PACS, 76 subjects (37.4%) had PAC/PACG, 14 (6.9%) had primary open angle glaucoma, and 45 (22.2%) subjects were normal with open angles. There was a weak but significant correlation between the angle opening distance (AOD), trabecular iris space area (TISA) and angle recess area (ARA) with clock hours of PAS (Spearman's correlation coefficients = -0.30, -0.32 and -0.32, respectively, p<0.001). The mean values of the AOD, TISA and ARA in the nasal, temporal and inferior quadrants were significantly less in eyes with PAS compared with those without (p<0.001, Mann-Whitney U test). Analysis by quadrant showed that these parameters were smaller in the nasal and temporal quadrants in eyes with PAS (p<0.01).
Angle width determined by AS-OCT and the extent of PAS were weakly correlated, and angle width was significantly smaller in eyes with PAS.
评估眼前节光学相干断层扫描（AS - OCT）测定的房角宽度与周边前粘连（PAS）的存在之间的关系。
这是一项前瞻性观察性病例系列研究，招募了203例原发性房角关闭或开角的受试者。在暗室条件下用AS - OCT获取鼻侧、颞侧和下方房角的图像。然后由一位对AS - OCT检查结果不知情的独立检查者进行前房角镜检查。通过前房角镜检查确定PAS，并将其定义为虹膜与房角的异常粘连，宽度至少为半个钟点，且延伸至前小梁网或更高水平。记录PAS的总钟点数。
68例受试者（33.5%）为原发性房角关闭疑似患者（PACS），76例受试者（37.4%）患有原发性房角关闭/原发性闭角型青光眼（PAC/PACG），14例（6.9%）患有原发性开角型青光眼，45例（22.2%）受试者房角开放正常。房角开放距离（AOD）、小梁虹膜空间面积（TISA）和房角隐窝面积（ARA）与PAS的钟点数之间存在弱但显著的相关性（Spearman相关系数分别为 - 0.
30、- 0.32和 - 0.32，p<0.001）。与无PAS的眼睛相比，有PAS的眼睛鼻侧、颞侧和下方象限的AOD、TISA和ARA的平均值显著更小（p<0.001，Mann - Whitney U检验）。按象限分析表明，有PAS的眼睛鼻侧和颞侧象限的这些参数更小（p<0.01）。
AS - OCT测定的房角宽度与PAS的程度呈弱相关，且有PAS的眼睛房角宽度显著更小。
