Reznicek Lukas, Dabov Simeon, Haritoglou Christos, Kampik Anselm, Kernt Marcus, Neubauer Aljoscha S
Department of Ophthalmology, Ludwig Maximilians University, Mathildenstr. 8, Munich 80336, Germany.
Int J Ophthalmol. 2013;6(1):75-80. doi: 10.3980/j.issn.2222-3959.2013.01.16. Epub 2013 Feb 18.
To evaluate the role of central green-light fundus autofluorescence (FAF) in diabetic macular edema (DME).
A consecutive series of 92 study eyes with diabetic retinopathy were included. Out of those, 51 diabetic eyes had DME and were compared to 41 diabetic eyes without DME. In all subjects, green-light FAF images were obtained, quantified and classified into various FAF patterns. Cross-sectional optical coherence tomography (OCT) scans were obtained for evaluation of Inner/Outer segment (IS/OS) layer integrity, measurements of central RPE-IS/OS layer thickness as well as classification of DME into various subtypes.
Mean central green-light FAF intensity of eyes with DME (1.289±0.140)log did not significantly differ from diabetic patients without DME (1.317±0.137)log. Most classifiable FAF patterns were seen in patients with cystoid DME. Mean central retinal thickness (CRT) of all study eyes with DME was (501.9±112.4)µm compared to (328.2±27.0)µm in diabetic patients without DME. Patients with DME had significantly more disrupted photoreceptor IS/OS layers than diabetic patients without DME (28/51 vs 5/41, P<0.001). Mean RPE-IS/OS thickness of patients with DME (60.7±14.1)µm was significantly (P<0.001) lower than in diabetic eyes without DME (73.5±9.4)µm. Correlation analys1s revealed non-significant correlations of green-light FAF intensity and OCT parameters in all subtypes of DME.
Our results indicate a poor correlation of central green-light FAF intensity with CRT, IS/OS layer integrity or RPE-IS/OS layer thickness in diabetic patients with or without DME and its various subtypes. Thus, central green-light FAF is not suitable for detection of retinal thickening in DME.
评估中心绿光眼底自发荧光（FAF）在糖尿病性黄斑水肿（DME）中的作用。
纳入连续的92只患有糖尿病性视网膜病变的研究眼。其中，51只糖尿病眼患有DME，并与41只无DME的糖尿病眼进行比较。对所有受试者获取绿光FAF图像，进行量化并分类为各种FAF模式。获取横断面光学相干断层扫描（OCT）以评估内/外节（IS/OS）层的完整性、测量中心视网膜色素上皮-IS/OS层厚度以及将DME分类为各种亚型。
患有DME的眼睛的中心绿光FAF平均强度（1.289±0.140）log与无DME的糖尿病患者（1.317±0.137）log无显著差异。在囊样DME患者中可见到大多数可分类的FAF模式。所有患有DME的研究眼的平均中心视网膜厚度（CRT）为（501.9±112.4）μm，而无DME的糖尿病患者为（328.2±27.0）μm。与无DME的糖尿病患者相比，患有DME的患者的光感受器IS/OS层破坏明显更多（28/51对5/41，P<0.001）。患有DME的患者的平均视网膜色素上皮-IS/OS厚度（60.7±14.1）μm显著低于（P<0.001）无DME的糖尿病眼（73.5±9.4）μm。相关性分析显示，在DME的所有亚型中，绿光FAF强度与OCT参数之间无显著相关性。
我们的结果表明，无论有无DME及其各种亚型，中心绿光FAF强度与CRT、IS/OS层完整性或视网膜色素上皮-IS/OS层厚度之间的相关性较差。因此，中心绿光FAF不适用于检测DME中的视网膜增厚。
