Ducos de Lahitte G, Terrada C, Tran T H C, Cassoux N, LeHoang P, Kodjikian L, Bodaghi B
Department of Ophthalmology, Pitié-Salpêtrière Hospital, 47 bd de l'Hôpital, Paris, France.
Br J Ophthalmol. 2008 Jan;92(1):64-9. doi: 10.1136/bjo.2007.120675. Epub 2007 Jun 21.
The aim of this study was to examine the frequency and characteristics of macular lesions observed in juvenile idiopathic arthritis (JIA) uveitis, using optical coherence tomography (OCT).
In this cross-sectional study, 38 consecutive patients were recruited from a tertiary referral center in uveitis. All eyes with JIA uveitis underwent complete ophthalmic examination including OCT 3. Exclusion criterion was the inability to obtain OCT scans. Flare and visual acuity were also analysed by using linear regression.
We analysed foveal thickness (FT) and central foveal thickness (CFT), using software mapping, to describe macular lesions in 61 eyes. Maculopathy was observed in 51 eyes (84%) compared with 12% in the literature (p<0.0001) and comprised four types: perifoveolar thickening in 45 eyes (74%), macular oedema in 29 eyes (48%), foveal detachment in 11 eyes (18%) and atrophic changes in six eyes (10%). Only four eyes did not demonstrate any lesion.
Among children with JIA uveitis, macular involvement is frequent and characterised by perifoveolar thickening and serous retinal detachment. OCT is a non-invasive instrument. It can easily identify this maculopathy, which could impair visual function, and require therapeutic intensification.
本研究旨在利用光学相干断层扫描（OCT）检查幼年特发性关节炎（JIA）葡萄膜炎中黄斑病变的发生率及特征。
在这项横断面研究中，从一家葡萄膜炎三级转诊中心连续招募了38例患者。所有患有JIA葡萄膜炎的眼睛均接受了包括OCT 3在内的全面眼科检查。排除标准是无法获得OCT扫描结果。还通过线性回归分析了炎症和视力。
我们使用软件测绘分析了61只眼中的黄斑中心凹厚度（FT）和中央黄斑中心凹厚度（CFT），以描述黄斑病变。51只眼（84%）观察到黄斑病变，而文献报道为12%（p<0.0001），包括四种类型：45只眼（74%）出现黄斑中心凹周围增厚，29只眼（48%）出现黄斑水肿，11只眼（18%）出现黄斑中心凹脱离，6只眼（10%）出现萎缩性改变。只有4只眼未显示任何病变。
在患有JIA葡萄膜炎的儿童中，黄斑受累很常见，其特征是黄斑中心凹周围增厚和浆液性视网膜脱离。OCT是一种非侵入性检查仪器。它可以轻松识别这种可能损害视觉功能并需要加强治疗的黄斑病变。
