Brannan T, Martinez-Tica J, Yahr M D
Department of Neurology, Mount Sinai School of Medicine, New York, N.Y. 10029.
Neuropharmacology. 1991 Oct;30(10):1125-7. doi: 10.1016/0028-3908(91)90143-y.
We varied the diet of rats and monitored extracellular levels of dopamine in the striatum. Following L-dopa administration, the increase in striatal dopamine levels was attenuated by 78% in rats that had consumed a high protein diet as opposed to a low protein diet. Similarly, the increase in striatal dopamine levels was attenuated by 61% in rats that had just eaten a protein-containing meal as compared to fasting animals. These findings demonstrate that dietary protein strongly affects brain dopamine formation from exogenous L-dopa.
我们改变了大鼠的饮食，并监测纹状体中多巴胺的细胞外水平。给予左旋多巴后，与低蛋白饮食的大鼠相比，食用高蛋白饮食的大鼠纹状体多巴胺水平的增加减弱了78%。同样，与禁食动物相比，刚进食含蛋白质餐食的大鼠纹状体多巴胺水平的增加减弱了61%。这些发现表明，膳食蛋白质强烈影响外源性左旋多巴形成脑多巴胺的过程。
