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Effect of long-term L-dopa administration on striatal extracellular dopamine release.

作者信息

Brannan T, Martinez-Tica J, Yahr M D

机构信息

Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029.

出版信息

Neurology. 1991 Apr;41(4):596-8. doi: 10.1212/wnl.41.4.596.

DOI:10.1212/wnl.41.4.596
PMID:2011263
Abstract

When L-dopa was administered acutely to rats, the increase in the extracellular level of dopamine in the corpus striatum was attenuated by 43% in animals that had received L-dopa daily for 60 days as compared with animals receiving placebo. These findings indicate that chronic treatment with L-dopa impairs striatal dopamine formation or release.

摘要

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