海马注射新斯的明所诱导的高血糖症可被下丘脑内注射阿托品所抑制。

Hyperglycemia induced by hippocampal administration of neostigmine is suppressed by intrahypothalamic atropine.

作者信息

Iguchi A, Uemura K, Kunoh Y, Miura H, Ishiguro T, Nonogaki K, Tamagawa T, Gotoh M, Sakamoto N

机构信息

Third Department of Internal Medicine, Nagoya University School of Medicine, Japan.

出版信息

Neuropharmacology. 1991 Oct;30(10):1129-31. doi: 10.1016/0028-3908(91)90144-z.

DOI:10.1016/0028-3908(91)90144-z

PMID:1758588

Abstract

We investigated the relationship between the hyperglycemia induced by the administration of neostigmine into the hippocampus and the hypothalamus. Prior to the injection of neostigmine (5 x 10(-8) mol) into the hippocampus, 1 microliter each of atropine or hexamethonium (5 x 10(-11)-5 x 10(-8) mol) was injected into the bilateral ventromedial hypothalamus (VMH). Atropine suppressed in a dose-dependent manner the hyperglycemia induced by hippocampal administration of neostigmine, whereas hexamethonium had no significant effect. These observations suggest that the pathway for this experimental hyperglycemia involves, at least in part, the muscarinic cholinergic neurons in the VMH.

摘要

我们研究了向海马体和下丘脑注射新斯的明所诱导的高血糖之间的关系。在向海马体注射新斯的明（5×10⁻⁸摩尔）之前，将1微升阿托品或六甲铵（5×10⁻¹¹ - 5×10⁻⁸摩尔）分别注射到双侧腹内侧下丘脑（VMH）。阿托品以剂量依赖性方式抑制了海马体注射新斯的明所诱导的高血糖，而六甲铵则没有显著影响。这些观察结果表明，这种实验性高血糖的途径至少部分涉及VMH中的毒蕈碱胆碱能神经元。