在麻醉大鼠中，向下丘脑而非海马内注射蝇蕈醇可抑制海马新斯的明诱导的高血糖。

Intrahypothalamic, but not hippocampal, administration of muscimol suppresses hyperglycemia induced by hippocampal neostigmine in anesthetized rats.

作者信息

Ozawa K, Miura H, Tamagawa T, Hiyoshi Y, Nonogaki K, Maeda N, Watanabe G, Sakamoto N, Iguchi A

机构信息

Third Department of Internal Medicine, Nagoya University School of Medicine, Japan.

出版信息

Life Sci. 1993;53(25):1903-9. doi: 10.1016/0024-3205(93)90030-7.

DOI:10.1016/0024-3205(93)90030-7

PMID:8255151

Abstract

We investigated the effects of intrahypothalamic or hippocampal injection of GABA receptor agonists on hyperglycemia induced by hippocampal neostigmine. Prior to the injection of neostigmine (50 nmol) into the hippocampus (HPC), muscimol (0.01-1 nmol) or baclofen (1 nmol) was injected into the bilateral ventromedial hypothalamus (VMH). Muscimol suppressed the hyperglycemia in a dose-dependent manner, but baclofen affected it only minimally. In contrast, neither hippocampal muscimol (1 or 2.5 nmol) nor baclofen (1 nmol) suppressed the hippocampal neostigmine-dependent hyperglycemia. Intrahypothalamic muscimol (1 nmol) also decreased the changes in hepatic venous plasma glucagon and epinephrine significantly. These results indicate that intrahypothalamic muscimol suppresses hyperglycemia caused by cholinergic neurons originating from the HPC, indicating existence of the location specificity.

摘要

我们研究了下丘脑内或海马内注射GABA受体激动剂对海马新斯的明诱导的高血糖的影响。在向海马（HPC）注射新斯的明（50 nmol）之前，将蝇蕈醇（0.01 - 1 nmol）或巴氯芬（1 nmol）注射到双侧腹内侧下丘脑（VMH）。蝇蕈醇以剂量依赖的方式抑制高血糖，但巴氯芬对其影响极小。相反，海马内注射蝇蕈醇（1或2.5 nmol）和巴氯芬（1 nmol）均未抑制海马新斯的明依赖性高血糖。下丘脑内注射蝇蕈醇（1 nmol）也显著降低了肝静脉血浆胰高血糖素和肾上腺素的变化。这些结果表明，下丘脑内注射蝇蕈醇可抑制由源自HPC的胆碱能神经元引起的高血糖，表明存在位置特异性。