Setsuie Rieko, Wada Keiji
Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8502, Japan.
Neurochem Int. 2007 Jul-Sep;51(2-4):105-11. doi: 10.1016/j.neuint.2007.05.007. Epub 2007 May 24.
Parkinson's disease (PD) and Alzheimer's disease (AD), the most common neurodegenerative diseases, are caused by both genetic and environmental factors. Ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) is a deubiquitinating enzyme that is involved in the pathogenesis of both of these neurodegenerative diseases. Several functions of UCH-L1, other than as an ubiquitin hydrolase, have been proposed; these include acting as an ubiquitin ligase and stabilizing mono-ubiquitin. This review focuses on recent findings on the functions and the regulation of UCH-L1, in particular those that relate to PD and AD.
帕金森病（PD）和阿尔茨海默病（AD）是最常见的神经退行性疾病，由遗传和环境因素共同引起。泛素羧基末端水解酶L1（UCH-L1）是一种去泛素化酶，参与这两种神经退行性疾病的发病机制。除了作为泛素水解酶外，UCH-L1还具有其他几种功能；这些功能包括作为泛素连接酶和稳定单泛素。本综述重点关注UCH-L1功能和调节方面的最新研究发现，特别是与PD和AD相关的发现。
