Chandrashekara S, Jayashree K, Veeranna H B, Vadiraj H S, Ramesh M N, Shobha A, Sarvanan Y, Vikram Yeragani K
Chanre Rheumatology and Immunology Center, Clinical Immunology and Rheumatology, Bangalore, Karnataka, India.
J Psychosom Res. 2007 Jul;63(1):65-9. doi: 10.1016/j.jpsychores.2007.03.001.
Psychological stress can influence the immune system, which may result in stress-related illnesses. In this study, we investigated the effect of psychological stress and the coping skill on plasma cytokine levels.
One hundred eighty-three students, at different stages of an academic year, participated in this study. Plasma tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-2 soluble receptor alpha, and IL-4 were measured and examined in relation to the measures of anxiety [State Anxiety Inventory (SAI)] and Bell Adjustment Inventory (BAI) score.
SAI scores were significantly higher in both midterm students (MTS) and examination-taking students (ETS), compared with the freshly admitted students (FAS). In addition, TNF-alpha levels were significantly different between the high- and the low-anxiety groups of ETS but not in MTS or FAS. The correlation between SAI scores and the BAI emotional scores was highest in the ETS group.
TNF-alpha level was significantly lower in the ETS group with high anxiety scores, and it is situation specific.
心理压力会影响免疫系统，这可能导致与压力相关的疾病。在本研究中，我们调查了心理压力和应对技巧对血浆细胞因子水平的影响。
183名处于学年不同阶段的学生参与了本研究。检测并分析了血浆肿瘤坏死因子α（TNF-α）、白细胞介素（IL）-2可溶性受体α和IL-4，并将其与焦虑测量指标[状态焦虑量表（SAI）]和贝尔适应量表（BAI）得分相关联。
与新生（FAS）相比，中期学生（MTS）和应试学生（ETS）的SAI得分均显著更高。此外，ETS的高焦虑组和低焦虑组之间TNF-α水平存在显著差异，但MTS或FAS中无此差异。SAI得分与BAI情绪得分之间的相关性在ETS组中最高。
高焦虑得分的ETS组中TNF-α水平显著较低，且具有情境特异性。
